Предпосылки разработки новой смеси для вскармливания здоровых детей с комплексом пребиотических олигосахаридов scGOS/lcFOS, 3’GL и постбиотиками

Abstract

Breast milk is the best nutrition for an infant. When breastfeeding is not possible, it is critical to choose an infant milk formula that functionally resembles breast milk effects. The current strategy in the industry of human milk substitutes is aimed at modulating gut microbiota via functional components of the «biotic» family (pre-, pro-, syn-, postbiotics). The most scientific interest lies in the area of numerous prebiotic oligosaccharides of human milk (HMOs). It is possible to combine several prebiotic oligosaccharides with different structures and mechanisms of action in infant formula designed to reproduce the compound effects of HMOs. In this regard, the best studied scGOS/lcFOS (9:1) receive more and more evidence of the efficiency and synergistic action with other prebiotic oligosaccharides. The special class of functional components – postbiotics – was described due to recent discoveries in milk base fermentation process. One of the most promising among them is 3’-galactosyllactose (3’-GL). 3’-GL is produced by bacteria during the fermentation process and it is structurally identical to 3’-GL, which is naturally found in colostrum, transitional and mature breast milk. The first results of in vivo and in vitro studies demonstrated the safety and good tolerance, as well as promising local and systemic effects of a formula with 3’-GL, and especially in combination with the scGOS/lcFOS prebiotics (9:1) Key words: human milk substitutes, formula, human milk oligosaccharides, microbiota, biotics, prebiotics, postbiotics, 3’-GL, 3-galactosyllactose