Abstract
Purpose. To evaluate time-related OCT-A changes in patients with preclinical diabetic retinopathy and to identify OCT-A biomarkers of progression. Methods. A total of 42 diabetes mellitus (DM) patients (73 eyes) were recruited in the study. All patients underwent 7-field fundus photography, optical coherence tomography (OCT) and OCT-angiography (OCT-A). The examination was repeated in one and two years. Assessed OCT-A parameters included foveal avascular zone (FAZ) area, acircularity index (AI), vessel density (VD0-300 and VD300-600), skeletonized density. Results. FAZ area was significantly enlarged after two years of observation (0.25 ± 0.05 mm² and 0.28 ± 0.06 mm² , respectively, р< 0,0001). After a year of observation AI was significantly higher (1.37 ± 0.18 and 1.47 ± 0.20, respectively, р= 0.01) and VD0-300 was decreased in SVP and DCP. Logistic regression and ROC-analysis were used to identify biomarker of DR progression – VD0-300 in SVP, AUC = 0.821. Conclusions. To conclude, FAZ area and AI were significantly increased in follow-up visits. According to logistic regression analysis, VD0-300 in SVP can be the most appropriate OCT-A biomarker of preclinical DR progression. Keyword: diabetic retinopathy, vessel density, OCT-angiography.
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