Abstract
An early proinflammatory stress produced by administration of LPS (50 mcg/kg, sc) on 3rd and 5th postnatal days led to decrease of locomotor and search activity and increase of anxiety in rats at the age of 1 month in the tests of an open field and elevated plus maze. The males showed more anxious behavior than females. Administration of LPS in early ontogenesis produced the signs of depressive-like behavior in males and females in the test of anhedonia by decrease of preference of 1% sucrose solution in comparison with control groups. The forced swimming test showed the signs of depressive-like behavior in males, but not in females at the first day of testing at the age of 1 month. At the age of 3 months the all mentioned changes in anxious and depressive-like behavior were practically disappeared. The data obtained point out to the sex differences in the effects of early proinflammatory stress on anxious and depressive-like behavior in rats.
Published Version
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