Abstract
Schizophrenia is associated with neurochemical, morphological, bioelectrical and behavioral changes that make up the system of mutually complementary pathophysiological theories. In this paper, we review the neurochemical theory of the pathogenesis of schizophrenia from the standpoint of neuropsychopharmacology in order to explain and understand the mechanism of action of antipsychotic drugs. The relationship between neurochemical, genetic and immunological factors for schizophrenia is described. The paper provides up-to-date information on ligands, receptor targets and secondary messengers that are involved in the pathogenesis of schizophrenia and psychosis with a detailed explanation of their physiological role and their connections at the neurochemical, anatomical, functional and effector levels of the brain connective organization. Keywords: schizophrenia, antipsychotic drugs, neuroleptics, neuropsychopharmacology, dopamine, serotonin, glutamate, cytokines, neuropeptid
Published Version
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