Влияние модели разового вахтового труда в высокогорье на поведение и структурную организацию мозжечка

Abstract

In Kyrgyzstan, 94% of the entire territory of the country is occupied by mountains. There are significant resources located here, the development of which is often associated with the temporary ascent to significant heights and descent to the low mountains of specialists in various fields of work. At the same time, information about the state of brain structures and the behavior of animals and humans in these conditions is scarce. Objective: to study the influence of the model of a one-time 8-hour shift work in the highlands on the histophysiology of the cerebellum and individual behavior of rats. The work was performed on 28 white mongrel male rats weighing 250–310 g. The low-mountain series of the experiment was carried out at an altitude of 760 m above sea level (Bishkek). The high-altitude series was modeled on the Tuya-Ashu pass-3200 m above sea level (Kyrgyzstan). Behavioral activity was evaluated using the Open field method, muscle strength according to the S. V. Speransky method on the 3rd day of the experiment. The microcirculation of the cerebellum was studied microscopically under the Olympus B×40 light microscope (Japan). Statistical processing of the obtained data was carried out in the SPSS 16.0 program. In the highlands, the indicators of the mink reflex increase by 1.43 times, and the level of defecation increases by 8.5 times, which is a marker of increased vegetative activity of the body. Remodeling of cerebellar angioarchitectonics in the highlands is characterized by hypercapillarization, signs of blood stagnation, perivascular edema, enlargement of nucleoli, moderate hyperchromia of neurons of the molecular and granular layers. Thus, in the highlands, changes in behavioral activity are more pronounced than the remodeling of capillaries, neurons and glial elements, which are adaptive in nature.