Abstract
The variety of metabolic functions of protein hormones - leptin and ghrelin - determines the difference in the therapeutic approach to the treatment of patients with metabolic syndrome. This paper presents the results of a study of the leptin and ghrelin levels in serum of patients with metabolic syndrome. It was revealed that hyperleptinemia was observed in 20.2% of patients with the most obese women II and III than in men. Leptin resistance is also more common in women than in men by 36.4%. However, the ratio of leptin / BMI against compliance with the recommendations for the treatment of metabolic syndrome in men decreased by 2.1 times faster than that of women. Ghrelin levels remained high in patients with the metabolic syndrome by obesity III and IV degree after ingestion. In these patients the strength of lowering the ghrelin level is proportional to time. The rate of gastric emptying was delayed , and the feeling of satiety did not come. This has contributed to an increase in the amount of food intake and body weight gain at the expense of adipose tissue , producing high levels of leptin. The continued high drop it ghrelin and leptin in serum of obese patients significantly impede range of therapeutic interventions.
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