СИНДРОМ ГУДПАСЧЕРА С УМЕРЕННЫМ ПОРАЖЕНИЕМ ПОЧЕК И ТОРПИДНЫМ ТЕЧЕНИЕМ ЛЁГОЧНОГО ПРОЦЕССА: КЛИНИЧЕСКИЙ СЛУЧАЙ

Abstract

Anti-GBM antibody disease (Goodpasture syndromee) is a rare immunecomlpex vasculitis, affecting small vessels, and characterized by rapidly progressive glomerulonephritis and alveolitis. Causative mechanism is defined by the hyperproduction of autoantibodies against the α3-chain of type IV collagen (Goodpasture antigen) with immune complex formation on the glomerular and alveolar basement membrane. Typically patients with fnti-GBM antibody disease present with rapidly progressive (crescentic) glomerulonephritis, more than in half of cases associated with alveolar hemorrhage. Cases of Anti-GBM antibody disease with atypical clinical presentation have been reported. We report a case of atypical clinical presentation anti-GBM antibody disease with mild renal damage and slow progression of pulmonary involvement. Main CT signs were multiple centrilobular ground glass nodules. This case report demonstrates that CT with disseminated pulmonary process associated with even mild kidney involvement in patients with high anti-GBM antibodies titers gives a clue to the diagnosis of anti-GBM antibody disease.