НИКОТИНОВАЯ ЗАВИСИМОСТЬ И ГОРМОНАЛЬНЫЙ ДИСБАЛАНС У БЕРЕМЕННЫХ КУРИЛЬЩИЦ С РАЗНОЙ СТЕПЕНЬЮ ТЯЖЕСТИ ХОБЛ

Abstract

Introduction. The relationship between the degree of nicotine addiction and the functional state of the thyroid gland, the adrenocorticotropic hormone-cortisol system and hormone imbalance in pregnant women smokers with chronic obstructive pulmonary disease was studied. Aim. The aim of the study was to identify and evaluate the relationship between the degree of nicotine dependence and hormonal imbalance of the thyroid gland, cortisol and progesterone in pregnant smokers with varying degrees of chronic obstructive pulmonary disease severity. Material and methods. The study is based on the results of studying changes in blood hormone indicators in 107 smoking women with chronic obstructive pulmonary disease and 136 non-smoking women in different trimesters of pregnancy observed in the antenatal clinic. The control group consisted of healthy non-smoking patients. The diagnosis of chronic obstructive pulmonary disease was made based on the clinical recommendations of the Russian Respiratory Society (2021). The reliability of the results was evaluated using parametric statistics methods. The data obtained were processed using the Statistica 10 program, Microsoft Excel 2010. Results and discussion. The presented data revealed the presence in smokers of a statistically significant and very close relationship between the degree of nicotine dependence and the indicators of the imbalance of the hormones studied in all trimesters of pregnancy, with maximum values in the third trimester.This is due to the fact that it is in the third trimester of pregnancy that the maximum increase in the indicators of all studied hormones occurs, even if at the initial stage of pregnancy the indicator could be less than the lower limit of the reference interval, as in the case of thyroid-stimulating hormone.Conclusion. Nicotine addiction creates environment for the development of endocrine imbalance of thyroid hormones, adrenocorticotropic hormone, cortisol and progesterone.