Моделювання динаміки інфекційного захворювання з урахуванням просторово-дифузійних збурень, зосереджених впливів та кривизни середовища

Abstract

While the study of the interaction patterns of the immune system and the viruses detected in the body wide variety of models is used. Well-known infectious disease model by Marchuk which describes the most common mechanisms of immune defense, was obtained under the assumption that the environment of the "organism" is homogeneous and unlimited, in which all the active factors of the process are instantly mixed. The approach proposed by the authors to take into account the influence of spatially distributed diffusion "redistributions" on the nature of the infectious disease provides an opportunity to detect the reducing effect the model level of maximum antigen concentration at the infection epicenter due to their diffusion "erosion" in the disease development. In particular, in cases where the viral particles concentration at the initial time or the intensity of a concentrated source of viruses in any part of the body of infection exceeds a certain critical level of the immunological barrier such an effect of diffusion "redistribution" in a short time reduces supercritical concentrations of viral particles to values, in particular, already below the critical level and their further neutralization may be ensured by the existing level of own antibodies concentration or requires a more economical procedure of injection with a lower donor antibodies concentration. In this article the infectious disease mathematical model is generalized to take into account the curvature of the bounded environment in the conditions of spatial diffusion perturbations, convection and the presence of various concentrated influences. The corresponding singularly perturbed model problem with delay is reduced to a sequence of "solvable" problems without delay. The influence of "curvature" of a limited environment on the development of an infectious disease in the conditions of diffusion perturbations, convection and concentrated influences is illustrated.