КЛІНІЧНІ ТА ДЕЯКІ ІМУНОЛОГІЧНІ ОСОБЛИВОСТІ ПРОЯВІВ ГЕРПЕСВІРУСНИХ УРАЖЕНЬ НЕРВОВОЇ СИСТЕМИ НА ФОНІ ПОСТКОВІДНОГО СИНДРОМУ

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The article presents data from the current literature on the relevance of a serious health problem, problems in the diagnosis of post-COVID syndrome, complications, complex T-cell and cross-talk immune system responses. A detailed analysis of the manifestations of central and peripheral nervous system lesions in herpesvirus infections with post-COVID syndrome is carried out and substantiated by the literature. The manifestations of immune responses and autoimmune changes in COVID-19 are presented. The aim of the study was to investigate the clinical and immunological features of the course of herpesvirus lesions of the nervous system in patients with and without post-COVID syndrome. We examined 96 patients with nervous system lesions of herpesvirus etiology who had a history of COVID-19 (on average 2-2.5 months before admission to the department). Patients who have had COVID are much more likely to have lesions of individual CNS (2.14 times), PTO dysfunction (2.1 times), diffuse neurological symptoms (2 times), mental disorders (1.8 times), sleep disorders (3.5 times) and fever (2.4 times). The authors of the article found that in patients with nervous system lesions against the background of post-COVID syndrome and activation of neurotropic pathogens, headac he, ataxia and autonomic dysfunction, diffuse neurological symptoms and pyramidal insufficiency were most common. The activity of autoantibodies to neuroantigens (myelin basic protein, NSE, S-100, and human general brain antigen) was determined in all patients. In patients with post-COVID syndrome, a statistically significant increase in the level of autoantibodies to myelin basic protein, S100 protein, and neurospecific enolase was detected compared to the control group. These data indicate a more severe course of nervous system lesions in the setting of post-COVID syndrome, which in turn is associated with deeper damage to the structures of the nervous system. Keywords: Long-COVID, nervous system injures, autoimmune response, herpesviruses.