Abstract
The problem of obesity in modern life is becoming more actual and is a serious social risk for human life. This problem is common despite social and professional affiliation, location, age and gender. Obesity is associated with an increase growth of adipose tissue. Today obesity isn't studied only as an excessive accumulation of fat in the body, but as a chronic multivariate disease associated with a number of serious metabolic, oncological, cardiological and other complications. Although a lot of research studies regulation and intracellular processes of adipogenesis, however the information about molecular mechanisms of remodeling of the extracellular matrix during an increase fat mass is limited. Matrix metalloproteinases (MMPs) can increase the plasticity of the matrix, thereby providing adipose tissue remodeling and / or adipocyte hypertrophy, play an additional role in the growth of adipose tissue associated with obesity, supporting the differentiation of adipose tissue progenitor cells. Our research is aimed at characterization of enzymatic activitiesof MMPs in adipose tissue of the rats with obesity. We found that active enzymes with a molecular weight > 100 kDa were found in the adipose tissue of rats for the development of obesity, which may result from the formation of homodimers in these pathological conditions.Also activities of the MMP-2, -9 increase during obesity. Future studies of enzymatic activity of MMPs of rat's adipocytes tissues will improve understanding the biochemical processes under the conditions of this pathology and development of new approaches to diagnosis and treatment of obesity principles.
Highlights
In this article, an inventory of the spider fauna of the Fastov district of the Kiev region was carried out, an annotated list of spiders was compiled and includes 84 spider species of 67 genera from 20 families
Встановлено, що за умови ожиріння у жировій тканині щурів були виявлені активні ферменти з молекулярною масою > 100 кДа, що може бути наслідком утворення гомодимерів за таких патологічних станів
Розвиток ожиріння пов'язаний із такими процесами, як гіпертрофія адипоцитів із подальшим залученням попередників адипоцитів і диференціюванням нових жирових клітин
Summary
An inventory of the spider fauna of the Fastov district of the Kiev region was carried out, an annotated list of spiders was compiled and includes 84 spider species of 67 genera from 20 families. Ми охарактеризували ферментативну активність ММП у жировій тканині щурів, що страждають ожирінням. Що експресія ММП-12 значно індукується в жировій тканині мишей з ожирінням, викликаним дієтою, та існують дані про його експресію, як у зрілих адипоцитах, так й у макрофагах жирової тканини.
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Schedule a callMore From: Bulletin of Taras Shevchenko National University of Kyiv. Series: Biology
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