Abstract
Abstract. The study shows the values of heart rate variability in patients with paroxysmal atrial fibrillation treated with allapinin monotherapy and a combination of allapinin with metoprolol, allapinin with sotahexal and allapinin with diltiazem with preventive antiarrhythmic therapy. Analysis of heart rate variability allows you to determine the state of the autonomic nervous system. A high probability of an unfavorable outcome of diseases of the cardiovascular system is observed with the predominance of the tone of the sympathetic nervous system and a decrease in the tone of the parasympathetic nervous system. A decrease in heart rate variability and a predominance of sympathetic nervous system tone are predictors of the occurrence of another paroxysm in patients with paroxysmal atrial fibrillation. Indicators of heart rate variability are of great importance in the selection of antiarrhythmic therapy. The initial predominance of the tone of the parasympathetic nervous system in comparison with healthy ones and the absence of negative dynamics after 1 year was recorded in patients with paroxysmal atrial fibrillation with allapinin monotherapy. Patients treated with a combination of allapinin and metoprolol had a predominance of the tone of the parasympathetic nervous system initially compared with the healthy group and a transition to sympathicotonia after 1 year compared with healthy, control and their own baseline values. Patients receiving allapinin and sotahexal had no significant differences either at the beginning of the study or after 1 year. Predominance of sympathetic nervous system tone was registered in patients treated with allapinin and diltiazem by the end of 1 year of the study in comparison with a group of healthy.
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