Иммунные и метаболические нарушения на системном и локальном уровне при бесплодии трубно-перитонеального генеза

Abstract

Objective. The establishment of immune and metabolic disorders at the systemic and local level in patients with infertility of tubal peritoneal genesis against the background of a chronic infectious-inflammatory process of the reproductive sphere in the stage of clinical remission before and after the basic pharmocotherapy. Material and methods. A total of 96 patients with verified diagnosis of secondary infertility of tubal peritoneal genesis against the background of a chronic infectious and inflammatory process of bacterial viral etiology in the remission stage were under observation. The parameters of the immune status, the intensity of lipid peroxidation processes and the state of the antioxidant system were detected in peripheral blood and cervicovaginal lavage. Results. Within 24 hours after diagnostic and treatment laparoscopy and basic pharmacotherapy had been conducted, the presence of immune inflammation, endothelial dysfunction, “oxidative stress”, activation of lipid peroxidation processes was established at the systemic and local level, as evidenced by changes in 97.8% of laboratory immunometabolic parameters from the studied data. After conducted basic treatment, this percentage decreased to 90.9%, while 9.1% returned to normal, 75.0% of contravene laboratory parameters were corrected, 15.9% remained unchanged at the same level before the treatment. Conclusion. The obtained results indicate that the conducted basic pharmacotherapy in this category of patients has no adequate corrective effect on the impaired parameters of the immune and metabolic status that requires the additional pharmacological immuno-rehabilitation resources in this category of patients during pharmacological rehabilitation.