Abstract
Modern drug therapy has radically changed approaches to the treatment of common skin melanoma. Unfortunately, some patients have no response to this therapy or the disease progresses after a while. In such a situation, we return to chemotherapy. Despite the resistance of melanoma to chemotherapy drugs, recent studies show that after the progression of the disease against the background of immunotherapy, the use of chemotherapy in late lines allows you to achieve results that are not inferior to those that were achieved earlier in the first line of treatment. This review is devoted to comparing the results of chemotherapy in patients with skin melanoma in late lines with the results obtained before the era of modern drug therapy.
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