Влияние компонентов метаболического синдрома на уровень стабильных метаболитов оксида азота у больных эссенциальной гипертензией

Abstract

Objective. To investigate levels of the stable nitric oxide metabolites (NOx) in relation to different components of the metabolic syndrome (MS) in essential hypertension (EH).Methods. We examined 124 untreated patients with EH and 25 healthy volunteers with comparable age.Results. NOx levels were significantly higher in hypertensives (43.18±21, mol/l) then in controls (28.3±9.6 mol/l); p <0.05. In patients with hyperglycemia NOx concentration was significantly higher (46.5±23.9 mol/l) than in those without it (38.6±18, mol/l); р <0.05. NOx levels correlated with blood glucose levels (r=0.32, p <0.05). Obese hypertensives had lower NOx concentration than nonobese hypertensives (38.8±17.9 and 48.5±24.7mol/l accordingly; р <0.05). NOx levels correlated with the presence (r=-0.44, p <0.05) and degree of obesity (r=-0.3, p <0.05). NOx levels were significantly lower in patients with MS (31.6±11.3 and 47.05±20.7 mol/l accordingly; р <0.05). NOx levels decreased with the increase of the quantity of MS components ( р <0.05). NOx levels correlated with the amount of MS components (r=-0.38, p <0.05). Hypertensives with high leptin levels had lower NOx concentration (29±12.2 mol/l), compared to hypertensives with normal leptin levels (34.7±10.5 mol/l); p <0.05.Conclusion. Hypertension per se and hyperglycemia increase NOx levels, whereas MS and its essential signs like visceral obesity and high plasma leptin level decrease NOx levels.