ОКСИДАНТНЫЙ СТРЕСС В ОРГАНИЗМЕ КОРОВ И ПЕРВОТЕЛОК В ПАТОГЕНЕЗЕ МЕТРИТА В РАННИЙ ПОСЛЕРОДОВОЙ ПЕРИОД

Abstract

The data established in the course of this work reveal the pathogenesis of metritis in fresh cows and first-calf heifers in the early puerperal period against the background of oxidative stress, in farms of various organizational and legal forms of ownership of the Volgograd, Saratov regions and the Chechen Republic of the Russian Federation. The use of indicators of the system "lipid peroxidation - antioxidant protection" (LPO-AOD) for the diagnosis of metritis in fresh cows and first-calf heifers has a high predictive reliability and, on this basis, the development of preventive measures for acute inflammation of the uterus. It was revealed that the increase in the amount of β-hydroxybutyric acids and their fractions (AcAc and BH) by 5.9 times, as well as mixing the content of buffer bases in the blood to 18.41 ± 1.53 mmol / L, glucose to 2.25 ± 0 , 16 mmol / l and the VL / AcAc index up to 1.53 ± 0.28 indicate abnormalities in metabolic metabolism characteristic of oxidative stress, with symptoms of postpartum acute metritis. It was confirmed that a 1.75-fold increase in the amount of manol dialdigide in this disease up to 1.125 ± 0.34 μmol / l, intermediate products of ketodienes, as well as conjugated trienes in the blood of fresh animals. Acute postpartum metritis in first-calf heifers and fresh-calf cows leads metabolic processes to a negative balance, increased release of estradiol and testosterone into the blood. Meanwhile, the content of cortisol (21.4 ± 3.47 ng / ml), as well as progesterone (11.2 ± 4.31 ng / ml) remains rather insignificant to ensure metabolic processes in the early pueperal period, which is associated with the completion of in the genitals of involutional processes. At the same time, the indicator of the ratio of progesterone to estradiol is significantly lower in heifers and cows with uterine disease in the primary postpartum period than in animals with its physiological course ranging from 1.8 to 2.2 times. The materials of the current work should be taken into account in the future, in the study of fresh cows and first-calf heifers suffering from acute postpartum metritis, as a concept for the development of the oxidative stress syndrome in such a pathology of metabolic processes.