Особливості патогенезу дисплазії грудних залоз без та на тлі генітальної патології у жінок перименопаузального віку

Abstract

The objective: studying of aspects of pathogenesis of dysplasia of mammary glands without and a background of genital pathology at women of perimenopause age. Materials and methods. Еxamination of 100 patients of perimenopause age about the diagnosis of dysplasia of mammary glands was conducted. The group of comparison was made by 50 women. Along with the standard methods, physical and ultrasonic researches of mammary glands, dopplerografiya with color Doppler mapping of a blood flow in parenchyma arteries, hormonal research, on displays – an intraoperative biopsy and morphological techniques. Results. Research of levels of molecular and biological markers showed that for detection of proliferative activity in mammary glands at patients with dysplasia of mammary glands it is expedient to carry out dynamic quantitative definition and when rising more than for 20% of several markers, for example IL-6, sFas, IL-1 β, is the direct indication for carrying out biopsy with the subsequent cytologic research of the received material for diagnostics of proliferative phenotype. Conclusion. highlights of pathogenesis of dysplasia of mammary glands are clinical-anamnestic data, and also changes of a zytokines exchange and the main molecular and biological markers. The received results need to be used when developing complex of diagnostic and prognostic actions. Key words: dysplasia of mammary glands, pathogenesis, genital pathology, perimenopause age.