Abstract
Objective. To study age-related interrelations between cytokine concentrations and parameters of physical development in children with inflammatory diseases of the oropharynx. Materials and methods. 50 children aged 3 to 14 years were examined. Serological tests were performed to determine cytokine concentrations in oronasopharyngeal secretion, their interrelationships, as well as physical development of children with assessment of anthropometric parameters using the centile method. Results. As was found, interleukin-1β concentrations in oral and nasopharyngeal secretions in the group of schoolchildren exceed more than twice this parameter in the group of preschool children. At the same time, the cytokine interferon-g in schoolchildren decreases as compared with preschool children. According to the results of our study, the deviations of the average group anthropometric parameters (body weight and length) in children with inflammatory diseases of the oronasopharynx from the normative values are determined by the dynamic of individual adaptive variability with the predominant restriction of weight parameters. Disharmonious physical development, increasing with age in children with limited adaptive variability, predominantly of weight characteristics, correlates with lower values of the similar characteristic of their local immune response. Conclusion. The results of adaptive immune response and interconnections between cytokine concentrations in oronasopharyngeal mucosa and the anthropometric parameters of children of varied age might serve as the diagnostic markers of local immune response and prognostic criteria for the course of inflammatory diseases of the oronasopharynx in this cohort of children. Key words: adenotonsillar complex, oronasopharynx, immune response, interleukin-1β, interferon-γ, physical development
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