Особенности ремоделирования сердца и сосудов у женщин с гипертонической болезнью в зависимости от степени ожирения

Abstract

The objective: was to establish the peculiarities of heart and vascular remodeling in the females with hypertension and obesity of different grades. Materials and methods. We examined 142 patients with hypertension at the age of 40–60 years. The first group included 25 patients with normal body weight, the second – 45 patients with grade 1obesity, the third group – 45 patients with grade 2obesity, and the fourth – 27 patients with grade 3 obesity. Results. As a result of the conducted research, it is established that the values of the studied parameters in patients with normal body weight and grade 1obesitydo not have a significant difference. In patients with grade 2 obesity, the size of the intima-media complex is statistically significantly higher, and the degree of endothelium-dependent vasodilation of the shoulder arteries is less than in patients with normal body weight. Unlike other groups, the patients with grade 3 obesity have the intima-media complex thickness, their pulse wave velocity in the carotid arteries and the abdominal aorta and the final diastolic size of the left ventricle of the heart are higher, but the endothelium-dependent vasodilation degree of the brachial arteries is significantly less. Conclusion. With the increase of the body weight, hypertensive females tend to increase the average pressure in the pulmonary artery and decrease the left ventricular ejection fraction. Key words: hypertension, obesity, heart and vascular remodeling.