Features of Vascular Remodeling in Patients with Hypertension and Obesity With or Without Insulin Resistance

Abstract

The objective: the study was to establish the features of vascular remodeling in patients with hypertension and obesity with or without insulin resistance.Materials and methods. We examined 174 hypertensive patients at the age of 45–55. The first group included 40 patients with normal body weight, the second – 45 patients with overweight, the third – 47 patients with grade I overweight and the fourth – 42 patients with grade II overweight. The control group consisted of 25 practically healthy individuals with normal body weight, comparable in age and gender with the main group.Results. It has been found that in hypertensive patients, starting from grade I overweight an increase in body mass index is accompanied by an increase in the pulse wave velocity in the carotid artery and a decrease in the degree of endothelium-dependent vasodilation, and grade II overweight is also accompanied by an additional increase in the intimamedia thickness and the pulse wave velocity in the abdominal aorta.Conclusion. Insulin resistant patients with hypertension have a significantly lower degree of endothelium-dependent vasodilation than hypertensive patients without insulin resistance.