Особливості перебігу алкогольної хвороби печінки на стадії цирозу у поєднанні з неалкогольною жировою хворобою печінки

Abstract

SummaryThe purpose was to study the features of clinical and laboratory manifestations ofalcoholic liver disease at the cirrhosis stage associated with non-alcoholic fatty liverdisease.Material and methods. Clinical, laboratory and instrumental examinations wereperformed for 204 patients with hepatic cirrhosis. 78 persons had alcoholic liver disease(Group I) and 126 persons had a combination of alcoholic liver disease with nonalcoholic fatty liver disease (Group II). Group I included 24 women and 54 men(53.2±7.6) years old; 22 women and 104 men (47.8±6.4) years old belonged to GroupII. Patients of Groups I and II were allocated to subgroups according to the classes ofhepatic cirrhosis compensation according to the Child-Pugh criteria: IA (17 patients),IB (38 patients), IC (23 patients); IIA (44 patients), ІІВ (48 patients), ІІС (34 patients).Results and discussion. It was found that the signs of astheno-vegetative, pain,dyspeptic, hepatorenal, hepatopulmonary syndromes, jaundice, medically uncontrolledascites, and manifestations of hepatic encephalopathy were shown more often amongpatients in combination with non-alcoholic fatty liver disease. Somatometric indicessignificantly differed among all patients depending on the degree of compensation. Thethickness of the skin and fat fold are reliable indicators that reflect the state of the fatdepot of the body; the circumference of shoulder muscles is a reliable indicator of thereduction of the somatic protein pool, accompanied by a decrease in the syntheticfunction of the liver and a decrease in the somatic protein pool, especially amongpatients associated with non-alcoholic fatty liver disease.Conclusions. During examining patients with liver cirrhosis, the study of the trophicstatus, synthetic function, and functional state of the liver are recommended for timelycorrection of the revealed disorders.