Abstract
Renal responses of hypertensive ISIAH and normotensive WAG rats to intragastrically administered isosmotic (0.9 %) and hyperosmotic (2 %) sodium chloride were studied. It was found, that ISIAH rats are characterized by more active water and sodium excretion under these loadings, while different mechanisms underlie the differences in the response of the kidneys of the ISIAH and WAG rats to iso- and hyperosmotic solutions. The greater efficiency of isoosmotic solution excretion in ISIAH rats was related to significant inhibition of sodium reabsorption in the renal tubules during the baroreceptor reflex as a result of reduced basal activity of renal renin-angiotensin system. When hyperosmotic solution was administered, the excretion rate of the load by ISIAH rats was associated with a more rapid development of the reaction, apparently due to the activation of prostaglandin secretion under hyperosmia, because the preliminary infusion of sodium diclofenac blocking their biosynthesis neutralized interstrain differences.
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