Abstract
ISIAH rats with inherited stress-induced arterial hypertension are characterized by increased stress reactivity of the hypothalamic-pituitary-adrenal and sympathoadrenal systems. The aim of this work was to study the genetic basis of increased susceptibility to stress in hypertensive ISIAH rats. Sequencing of the adrenal transcriptomes of hypertensive ISIAH and normotensive WAG rats revealed 9 differentially expressed genes (DEGs) in the X chromosome locus, which was previously associated with an increase in blood pressure and plasma corticosterone concentrations under mild emotional stress, and also with increased adrenal weight in ISIAH rats. An analysis of the functions of the proteins encoded by these DEGs suggested that the Sms gene encoding spermine synthase is the most likely candidate gene in the X chromosome locus associated with an increased level of stress susceptibility in ISIAH rats.
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