Изменения иммунологических показателей при использовании комбинированного физиотерапевтического метода в комплексном лечении атопического дерматита у детей

Abstract

The aim of this study was to evaluate changes in immunological parameters in children with atopic dermatitis when using hydrotherapy, non-selective chromotherapy, and intravenous laser irradiation of blood against the background of basic drug therapy. Materials and methods. The work was performed with the participation of 164 patients with moderate lichenoid and erythematous-squamous forms of atopic dermatitis aged 4 to 15 years with a frequency of exacerbations from 3 to 4 times a year with a tendency to increase their duration. The patients were divided into 5 groups: the first group received basic drug therapy (BDT), the second - hydrotherapy and BDT, the third - non-selective chromotherapy and BDT, the fourth - low-intensity laser irradiation of blood and BDT, the fifth - hydrotherapy, non-selective chromotherapy, low-intensity laser irradiation of blood and BDT. The content of total IgE, IL-4, IL-10, IL-13, IL-18 and TNF-α in the blood serum of patients was determined by enzyme immunoassay before treatment, as well as 1 and 3 months after its start. Results. Before the start of treatment, the values of all the studied indicators in comparison with healthy individuals were significantly increased (by 2.1-3.1 times). In patients of the first and second groups, the level of IgE and cytokines did not change significantly after 1 and 3 months from the start of treatment in comparison with the indicators before the start of treatment. In the third group, after 1 month from the start of treatment, the group experienced a significant (by 11-20%) decrease in IgE and cytokine levels, which persisted after 3 months of follow-up. In the fourth group, the decrease in the studied indicators after 1 month was even more significant and did not change significantly. The greatest decrease in indicators after 1 and 3 months was observed in the fifth group of patients (by 40-62%) who received basic drug therapy in combination with hydrotherapy, non-selective chromotherapy and intravenous laser irradiation of blood. Conclusion. In children with moderate atopic dermatitis, drug-based basic treatment combined with non-selective chromotherapy and intravenous laser irradiation of blood contributes to the effective correction of immunological reactivity for a long period of time.