Abstract
In this work, we have studied the impact of chronic alcohol intoxication (CAI) on reproductive function in male rats. Prolonged alcohol abuse has been shown to significantly reduce the manifestation rate of sexual activation and testosterone level in blood serum of male rats with CAI following exposure to a receptive female, as well as to change their seminal fl uid composition. The rhythmic craniocerebral hypothermia (rCCH), combined with the administration of cryopreserved cord blood leukoconcentrate (cCBL) ensured to a greater extent the dynamics of functional integrity recovery of the CAI-altered reproductive system in male rats, if compared to each of these methods used solely. The authors have hypothesized the rCCH and cCBL to activate the hypothalamicpituitary system, affecting thereby the testosterone synthesis and spermatogenesis stimulation.
Highlights
In this work, we have studied the impact of chronic alcohol intoxication (CAI) on reproductive function in male rats
The animals were divided into 5 groups (n = 15 in each): the group 1 comprised the intact rats; the group 2 was the rats with CAI (CAI control); the group 3 consisted of the rats with CAI, received the rhythmic craniocerebral hypothermia (rCCH) procedure; the rats with CAI, with administered cryopreserved cord blood leukoconcentrate (cCBL) were in the group 4; the rats with CAI, who underwent the combined methods of exposure were included in the group 5
Male rats in the preparatory phase, which allowed the animal to achieve the contact with the target object, demonstrated the following behaviors: the male moved along the barrier, sniffed the female, got up on its hind legs, touched the barrier with one or both forelegs, poked its nose into the holes or gnawed their edges in an attempt to get over the barrier and find its way to the female
Summary
We have studied the impact of chronic alcohol intoxication (CAI) on reproductive function in male rats. Prolonged alcohol abuse has been shown to significantly reduce the manifestation rate of sexual activation and testosterone level in blood serum of male rats with CAI following exposure to a receptive female, as well as to change their seminal fluid composition. The rhythmic craniocerebral hypothermia (rCCH), combined with the administration of cryopreserved cord blood leukoconcentrate (cCBL) ensured to a greater extent the dynamics of functional integrity recovery of the CAI-altered reproductive system in male rats, if compared to each of these methods used solely. Huss (1849), as the reflection of a systemic disease, that he considered to be a result of toxic ethanol damage to internal organs (brain, liver, heart, stomach, pancreas, intestines, etc.) [27]. A damaging effect of ethanol has been reported [1, 6, 9] as caused by Надійшла 30.03.2020 Прийнята до друку 09.11.2020
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