Abstract
The effect of obesity on reproductive function in obese men is much less investigated than in women. In addition, the mechanism of male reproductive outcomes in obesity is unknown. So this study was designed to investigate the effect of prepubertal induction of obesity on the reproductive function in male rats at maturity and to address whether inflammation and testicular oxidative stress are involved at the mechanistical level. Fourteen male albino rats, 4 weeks old were included and divided into control group (n=6) and high fat diet group (n=8). The animal characteristics were assessed, serum biochemical parameters, FSH, LH, testosterone, estradiol, TNFα, IL-6 and IL-10 were measured, sperm count and motility were measured, testicular oxidative stress markers were assayed and histopathological evaluation of spermatogenesis was done. HFD feeding induced significant increase in body weight, BMI, Lee index, serum cholesterol, triglycerides, TNFα and testicular malondialdehyde. HFD feeding induced significant decrease in relative testicular weight, IL-10, sperm count and progressive movement and testicular glutathione peroxidase. HFD group revealed defective spermatogenesis. Prepubertal induction of obesity impaired the reproductive function in mature male rats. Testicular oxidative stress and inflammation may be playing an important role in this effect.
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