ВЛИЯНИЕ НИЗКОИНТЕНСИВНОГО КРАСНОГО СВЕТА НА ОКИСЛИТЕЛЬНУЮ МОДИФИКАЦИЮ БЕЛКОВ ПРИ РАЗВИТИИ РАДИАЦИОННО-ИНДУЦИРОВАННОЙ БОЛЕЗНИ ЛЕГКИХ В ЭКСПЕРИМЕНТЕ

Abstract

The aim of the study was to investigate the content of spontaneous protein oxidative modification (POM) in the blood serum and pulmonary tissue of rats after local gamma irradiation of the projection area of the heart and lungs. The content of products of spontaneous POM (aliphatic neutral and basic aldehyde- and ketone-dinitrophenylhydrazones) in the blood serum and pulmonary tissue of 57 rats was studied. The animals were divided into 5 groups: “control group”, where there was gamma irradiation of the heart and lungs area, the collection of samples was done at the next day; “treatment group”, where a single session of low-intensity broadband red light was performed after local exposure to gamma radiation (the collection of samples was done at the next day); “chronic control group”, where there was an exposure to local gamma irradiation of the heart and lungs area, the collection of samples was done at the fourth day; “chronic treatment group” was daily exposed to low-intensity red light for 4 days after local exposure to gamma radiation, the collection of samples was done at the fourth day; “normal level group” was not exposed to either gamma radiation or broadband red light. In the pulmonary tissue and blood serum of control animals, a gradual increase in the content of spontaneous POM products was observed. The most significant difference from the normal level the “chronic control group” had. At the same time, the normalization of the content of POM products under the influence of low-intensity broadband red light in the tissues of the experimental groups was revealed. In the course of the experimental study, the normalization of processes of free radical oxidation of proteins in the lung tissue and in the serum of rats after gamma irradiation and the exposure of the projection region of the heart and lungs to low-intensity broadband red light was shown. Thus, low-intensity red light can be considered as a possible radioprotector.