Abstract
В експерименті на тваринах, уражених тетрахлорметаном, доведено антиоксидантні властивості настойки з листя хости ланцетолистої, що проявляється зниженням інтенсифікації процесів перекисного окиснення ліпідів та окиснювальної модифікації білків у сироватці крові та печінці щурів. Під її впливом відбувається зниження вмісту ТБК-активних продуктів та 2,4-динітрофенілгідразонів, підвищення активності каталази, вмісту відновленого глутатіону та зниження вмісту церулоплазміну в ураженому організмі.
Highlights
Lipid peroxidation activation (LPA) is nowadays considered as one of the main pathogenic mechanism of liver injury [3]
The aim of our study was to examine the effect of hosta lancifolia tincture on oxidative processes in the rat’s organism, damaged by tetrachloromethane
In rats’ organism, infected with carbon tetrachloride, the content of TBA-AP significantly increased in all terms of research (p≤0.05)
Summary
Lipid peroxidation activation (LPA) is nowadays considered as one of the main pathogenic mechanism of liver injury [3]. Hepatotrophic poison tetrachloromethane (ССl4) is used as a model of liver cells toxic injury. It intensifies free-radical processes and debilitates the organism [7]. That is why lately so much attention is paid to the problem of search and creation of medicinal products with antioxidant properties, especially, substances of natural origin. Low toxicity and benefits of herbal remedies over synthetic drugs (wide range of therapeutically active ingredients in medicinal plants, the possibility of combined use, low frequency of side effects) contributes to their widespread use in clinical practice and makes herbal substances a valuable source for new drugs [1, 11]. Our attention has been attracted by a widely cultivated plant, which is used in folk medicine and is called hosta lancifolia.
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