Аналіз показників клітинної та гуморальної ланок імунної системи у вагітних з парвовірусною інфекцією у різні періоди гестації

Abstract

The article covers the topic Parvovirus infection in pregnant women caused the development of immunopathological reactions. 129 in fected pregnant women and 16 women with physiological pregnancy in the 1st, 2nd and 3rd trimesters were examined. In infected pregnant women, activation of the cellular level of immunity was observed, a significant increase in the number of natural killers in the peripheral blood and an increase in the immunoregulatory index were detected, with greater deviations from the control indicators found in the 1st trimester. In pregnant women, in which clinical complications were noted, the population composition of lymphocytes was characterized by an increased number of NK cells, low infection with the number of cytotoxic CD8+-lymphocytes and a shift in the ratio of CD4+/CD8+totheside, which indicates an increase in helper mechanisms. Increasing the number of T-lymphocytes, T-helpercells, NK/Т cellsandactivated CD25+-lymphocytes in pregnant women with out clinical complications at different periods of pregnancy can contribute to effective elimination of the virus and to prevent severe fetal lesions. Violation of the humoral link of the immune system in the infection of pregnant parvovirus infection was shown in an increase in the serum IgM content in different periods of pregnancy (by 79.1%, 54.2% and 38.5%), and a decrease in IgA levels in the 1st and 2nd trimesters (p>0.05), to a greater extent such changes were found in women with clinical complications of pregnancy and especially in the first trimester. Key words: pregnancy, parvovirusinfection, cellular and humoral immunity.