Abstract
Abstract. Introduction. Multispiral computed angiography of the coronary arteries is the method of choice for the early noninvasive diagnosis of coronary atherosclerosis and, therefore, coronary heart disease. Quantitative indicators of epicardial fat depot are significantly associated with coronary atherosclerosis and coupled with possible cardiovascular events without reference to traditional risk factors. Aim of this study was to establish the relationship between the proinflammatory adipocytokine levels and the volumetric-linear parameters of paracardial fat depots in patients with coronary atherosclerosis. Materials and Methods. 135 patients (74 men (52%) and 61 women (48%)) with confirmed and suspected coronary heart disease were examined, aged 45 to 80 years. All patients were divided into 2 groups: Study group and comparison group. The study group consisted of 88 patients with coronary atherosclerosis, 56 men (63%) and 32 women (37%). This group included patients with one-, two- and multivessel coronary artery lesions, as well as with hemodynamically insignificant (CAD-RADs≤2) and significant (CAD-RADs≥3) stenosis areas. The comparison group consisted of 47 patients without coronary atherosclerosis. Quantitative indicators of cardiac and abdominal fat depots were calculated for all patients by means of computed tomography. Results and Discussion. The volume of epicardial adipose tissue was significantly higher in individuals with coronary heart disease, as compared to patients in the comparison group. The volume of abdominal adipose tissue was also higher in patients of the main group (p<0.001). The volume of visceral adipose tissue in patients with ischemic heart disease was 1.43 times larger than in the comparison group (p<0.05), the area of epicardial adipose tissue did not statistically differ in the two groups (p˃0.05), and the area of visceral adipose tissue was 1.62 times (p<0.05) larger in patients with ischemic heart disease. Differences in the groups with hemodynamically insignificant and significant coronary artery stenoses were statistically valid (p˂0.05). Conclusions. In patients with coronary artery disease, the degree of increase in epicardial and abdominal fat correlates with the severity of coronary artery atherosclerosis. Laboratory tests of the adipokine-cytokine profiles is an important prognostic factor of coronary atherosclerosis severity.
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