Коррекция куркумином и глицином нарушений легкой степени черепно-мозговой травмы у экспериментальных животных с различной степенью активности

Abstract

The aim of the research is to study the effect of the phytopreparation curcumin, the synthetic preparationglycine and the curcumin-glycine complex on the organism of animals with mild traumatic brain injury.Material and methods. Preclinical tests of curcumin, glycine and their complex on 90 laboratory whiteoutbred male rats weighing 210 ± 4.8 g, which are kept under standard conditions at the Central ScientificResearch Laboratory of the Tashkent Pharmaceutical Institute. Curcumin, glycine and their administrationat a dose of 75 mg / kg, then, after the reproduction of the model of mild brain injury in animals, the balance (system) was assessed using the «walk on a raised bar» test (walking on a raised bar).Results. The introduction of the curcumin + glycine complex had a more beneficial effect than monotherapy with curcumin and glycine, both on the levels of physical activity and on psychoemotional status.Conclusion. Analysis of the therapeutic effect of curcumin, glycine and curcumin + glycine complex onexperimental models showed that the most effective and rational for the correction of functional disordersin behavior is the use of the curcumin + glycine complex.