Abstract
Subject. The results of a comprehensive microbiological study of the state of the normobioma of the oral cavity in individuals with recurrent aphthae of the oral cavity against the background of acid-dependent diseases of the gastrointestinal tract are considered.
 The goal is to determine the diagnostic significance of individual representatives of the oral normobioma in patients with recurrent aphthae of the oral cavity against the background of acid-dependent diseases of the gastrointestinal tract.
 Methodology. The study involved 83 patients who were divided into two main and control groups depending on the clinical manifestations of recurrent aphthae of the oral cavity on the background of hypersecretory syndrome.
 Results. The results of the study showed that in patients of the first and second main groups, in which the manifestations of recurrent aphthae in the oral cavity were accompanied by diseases of the gastrointestinal tract with hypersecretory syndrome, the frequency of allocation of staphylococcal flora was 1.3—1.5 times higher compared to control (p≤0.05), an increase in the proportion of S. aureus — 2.5 times. The detection frequency of S. epidermidis in the control and both clinical groups was 28.0, 27.6 and 31.0 % of cases, respectively, the proportion of hemolytic forms in the control group was 4.0 %, in the first 10.3 % (an increase of 2 5 times), in the second — 17.2 % (4.3 times).
 The observed changes in the species composition may indicate dysbiosis in the oral cavity, caused not only by the presence of recurrent aphthae, but also by acid-dependent diseases of the gastrointestinal tract.
 Conclusions. In recurrent aphthae of the oral cavity in patients with acid-dependent diseases of the gastrointestinal tract in the microbiome of the oral cavity against the background of reduced titers of lactobacilli, an increase in representatives of Staphylococcus spp., Enterococcus spp is most often observed. and Candida spp. (1.2 times average), Enterococcus spp. (1.4 times), Staphylococcus spp. and Enterobacteriaceae spp. (1.2 times), Actinobacillus spp. (1.1 times).
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