Abstract
Nowadays, under conditions of an aging population, the comorbidity problem is of utmost importance in all branches of clinical medicine. The greatest difficulties are caused by the case when drug therapy of one nosology contradict with drugs prescribed for the treatment of another. In modern cardiology, extensive groups of diuretics and antihypertensives are widely used for therapy. At the same time, doctors do not always take into account the negative impact of cardiotropic therapy on the kidney stone disease process, as well as the general principles of metaphylaxis of nephrolithiasis on the cardiovascular system state. The paper presents data that allows to recommend the prescription of thiazides and combined antihypertensives, which have such in their composition, if the form of nephrolithiasis is idiopathic (stiff restriction). Besides, in conditions of urate nephrolithiasis, it is desirable to replace acetylsalicylic acid with clopidogrel, losartan with another sartan or an angiotensin-converting enzyme inhibitor. It is worth prescribing citrate mixtures with caution in metaphylaxis and nephrolithiasis litholysis, if there is no complete confidence in compensated cardiovascular diseases. KEYWORDS: recurrent nephrolithiasis, thiazides, potassium-sparing diuretics, gliflozines, losartan, acetylsalicylic acid, furosemide, acetazolamide, natural diuretics, urine pH. FOR CITATION: Yarovoy S.K., Royuk R.V. Difficulties and limitations in drug therapy of a patient with recurrent nephrolithiasis and concomitant chronic cardiovascular diseases. Russian Medical Inquiry. 2024;8(4):235–239 (in Russ.). DOI: 10.32364/2587-6821-2024-8-4-8.
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