Abstract
The objective of the study: modification of the standard IFA method aimed to detect antibodies against tuberculosis, assessment of its efficiency as a screening tool for prediction and diagnostics of tuberculosis in HIV patients. Subjects and methods. The modification of the standard IFA method aimed to assess the intensity of humoral anti-tuberculosis immune response included measurement of operational dilution of tested sera in order to enhance its diagnostic value. The modified method was used for the examination in the following groups: 85 active tuberculosis cases, 92 HIV patients with no clinical signs of tuberculosis, and 30 healthy donors. Results: it is possible to use the modified method in HIV positive people in order to detect those with the highest risk of tuberculosis among them; to provide early diagnostics of active tuberculosis, which is especially crucial at the advanced stages of HIV infection. This method cannot replace the classic methods of tuberculosis diagnostics and it is not recommended for mass screening in HIV negative persons.
Highlights
ОЦЕНКА ЭФФЕКТИВНОСТИ МОДИФИЦИРОВАННОГО ИФА-МЕТОДА ИДЕНТИФИКАЦИИ ПРОТИВОТУБЕРКУЛЕЗНЫХ АНТИТЕЛ ДЛЯ ПРОГНОЗА РАЗВИТИЯ И ДИАГНОСТИКИ ТУБЕРКУЛЕЗА У БОЛЬНЫХ ВИЧ-ИНФЕКЦИЕЙ
The modification of the standard IFA method aimed to assess the intensity of humoral anti-tuberculosis immune response included measurement of operational dilution of tested sera in order to enhance its diagnostic value
The modified method was used for the examination in the following groups: 85 active tuberculosis cases, 92 HIV patients with no clinical signs of tuberculosis, and 30 healthy donors
Summary
The modification of the standard IFA method aimed to assess the intensity of humoral anti-tuberculosis immune response included measurement of operational dilution of tested sera in order to enhance its diagnostic value. Results: it is possible to use the modified method in HIV positive people in order to detect those with the highest risk of tuberculosis among them; to provide early diagnostics of active tuberculosis, which is especially crucial at the advanced stages of HIV infection. Что данные методы хорошо идентифицируют стадию латентной туберкулезной инфекции (ЛТИ), они не могут дифференцировать ее от ранних этапов развития активного туберкулеза [7, 11, 12]. В анализируемой литературе мы нашли ряд работ, авторы которых допускали возможность использования серологических методов с разными наборами антигенов МБТ для прогноза развития активного туберкулеза у ВИЧ-позитивных лиц [10, 13]. Ранее выполненные нами исследования показали, что использование серологических методов в диагностике туберкулеза может быть более эффективным у лиц с ВИЧ-инфекцией [6]
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