Abstract
Extensively hydrolyzed cow’s milk protein formulas have been created for artificial feeding of children with cow’s milk allergy, and in most of them the carbohydrate and fat components are also significantly modified. This allows us to consider the use of this group of products not only in allergic diseases. For this purpose, it is necessary to reassess the experience of using these products in children with allergic diseases, considering the differences in the hydrolysis substrate, degree of hydrolysis, technology of producing dry powder, as well as the amount and composition of non-protein components, biologically active additives. This article reviews the physiology of protein digestion in infants and the interaction of dietary proteins with the immune system to demonstrate the opportunities and risks of using extensively hydrolyzed cow’s milk protein formulas in nonallergic diseases (short bowel syndrome and other forms of malabsorption, congenital heart disease with intestinal ischemia) and prematurity. Key words: children, hydrolysis, hydrolyzed protein, formulas
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