ДИНАМИКА КЛИНИКО-БИОХИМИЧЕСКИХ ПОКАЗАТЕЛЕЙ КРОВИ ЖИВОТНЫХ ПРИ ПРИМЕНЕНИИ СПИЦ С ИННОВАЦИОННЫМ ОСТЕОПЛАСТИЧЕСКИМ БИОКОМПОЗИЦИОННЫМ ПОКРЫТИЕМ ДЛЯ ВОССТАНОВЛЕНИЯ КОСТНОЙ ТКАНИ

Abstract

Injuries of the musculoskeletal system, of different types of animals, occur in more than 30% of the total number of non-infected animals. In veterinary and humane traumatology, the problem associated with fractures of tubular bones has not been completely solved. Due to the use of different methods of osteosynthesis, implying the use of various implants (spokes, bone plates, osteofixers, pins), it is fundamentally important to obtain such a coating on implants that satisfies such specified needs as: thickness, morphological heterogeneity, roughness, porosity, adhesive strength to accelerate consolidation processes. The article shows the results of studies on the dynamics of hematological and biochemical parameters of groups of experimental animals, in view of the use of osteoplastic biocomposition coating for spokes in combined osteosynthesis of tubular bones. Blood samples (n=60) served as the material for research. The purpose of this study was to assess the dynamics of hematological and biochemical parameters of blood during the implantation of spokes with the developed osteoplastic biocomposition coating. A group of authors, based on the dynamics of hematological parameters, determined that the coating consisting of hydroxyapatite, methyluracil, amoxicillin and polylactide does not cause hematopoiesis inhibition and acute inflammatory reaction. Based on the dynamics of biochemical parameters, it was determined that this coating does not have hepatotoxicity and nephrotoxicity, the absence of a negative effect of this material on the process of bone restoration and the formation of a callus was determined. The developed coating, from the point of view of the authors, allows for a sufficiently high degree of consolidation of bone fragments and the exclusion of such a factor as inflammatory processes.