ГЕМАТОБИОХИМИЧЕСКИЙ СТАТУС СОБАК ПРИ ИСПОЛЬЗОВАНИИ БИОКОМПОЗИЦИОННОГО ПОКРЫТИЯ ИМПЛАНТОВ ДЛЯ УСКОРЕНИЯ КОНСОЛИДАЦИИ КОСТНОЙ ТКАНИ

Abstract

Injuries of the musculoskeletal system of dogs occur in more than 30% of the total number of non-infectious pathologies. In veterinary and humane traumatology, the problems associated with fractures and their complications have not been fully resolved. Due to the use of different methods of osteosynthesis using different implants (spokes, bone plates, osteofixers, pins), it is quite important to apply coatings for these materials that met such specified needs as: thickness, morphological heterogeneity, roughness, porosity, adhesive strength and antibacterial effect to accelerate the consolidation processes. The article shows the results of studies on the dynamics of hematological and biochemical parameters of groups of experimental animals (dogs), in view of the use of osteoplastic biocomposition coating for implants (spokes) in intramedullary and extra-focal osteosynthesis of tubular bones. Animal blood samples (n=120) served as the material for research. The purpose of this study was to assess the dynamics of hematological and biochemical parameters of blood during the implantation of spokes with the developed osteoplastic biocomposition coating. A group of authors, based on the dynamics of hematological parameters, determined that the coating developed by them, consisting of hydroxyapatite, methyluracil, amoxicillin and polylactide, does not cause hematopoiesis inhibition and acute inflammatory reaction. Based on the dynamics of biochemical parameters, it was determined that this coating does not have hepatotoxicity and nephrotoxicity, the absence of a negative effect of this material on the process of bone restoration and the formation of a callus was determined. The developed coating, from the point of view of the authors, allows for a sufficiently high degree and speed of consolidation of bone fragments with the prevention of bacterial contamination.