Эффективность и безопасность применения терлипрессина при кесаревом сечении у беременных с высоким риском кровотечения: многоцентровое всенаправленное когортное исследование Terli-Bleed. Часть III

Abstract

The search for new means of prevention and treatment of massive obstetric haemorrhage is a priority task for the world scientific community, both obstetricians and anesthesiologists. Previously, we have shown the preventive efficiency of terlipressin, which helps to reduce the volume of blood loss during caesarean section (CS), and its lack of systemic hemodynamic effects when used topically. Objective. To evaluate changes in clinical and laboratory parameters when using terlipressin topically as a means of preventing postpartum haemorrhage during CS in high-risk pregnant women. Patients and methods. This publication is a continuation of our multicenter comprehensive cohort study of Terli-Bleed. The study included 454 pregnant women at high risk for haemorrhage who delivered by CS. They were divided into two groups: a control group (n = 351) and a study group (n = 103), with topical administration of terlipressin injected into the myometrium. Complete blood count, acid-base balance, lactate and hemostasis parameters were analyzed. Results. The levels of hemoglobin, platelets, fibrinogen, lactate, and blood pH were different in the groups during the postoperative follow-up period (p < 0.05). Conclusion. The analysis of clinical and laboratory parameters indicates the preventive ability of terlipressin to reduce the volume of intra- and postoperative haemorrhage without affecting the hemostasis system. Key words: terlipressin, caesarean section, postpartum haemorrhage, clinical and laboratory parameters