Abstract
Objective. To evaluate the dynamics of anthropometric indices and body composition in children with cystic fibrosis (CF) against the background of dietary correction with the use of semi-elemental and polymeric hypercaloric therapeutic formulas. Patients and methods. This was a single-center, retrospective, comparative study. Medical records of 40 children aged 5 to 10 years with a confirmed diagnosis of CF and a body mass index (BMI) less that the 50th percentile were analyzed. Children in the study group (n = 20) received a hypercaloric semi-elemental formula based on hydrolyzed protein; children in the comparison group (n = 20) received a hypercaloric formula for enteral nutrition based on whole protein. Both groups were comparable in age, sex, anthropometric and clinical characteristics. We assessed the comparative dynamics of anthropometric indices and body composition determined by bioimpedance analysis against the background of dietary correction for 90 ± 7 days. Results. The use of hypercaloric semi-elemental formula based on hydrolyzed protein was accompanied by an average increase in body weight by 1.8 kg, height by 2.2 cm, BMI by 0.7 kg/m2, and skeletal muscle mass by 1.7%. Similar results were obtained in the comparison group. No statistically significant differences between the groups regarding examined indicators were found. Conclusion. The retrospective analysis of using a hypercaloric semi-elemental formula based on hydrolyzed whey protein for the correction of nutritional deficiency in children with CF aged 5 to 10 years indicates its clinical efficacy for this category of patients. Key words: cystic fibrosis, children, malnutrition, hypercaloric formula, enteral nutrition, semi-elemental formula, intestinal syndrome, Peptamen Junior 1.5, malabsorpt
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