Зависимость эффективности фозиноприла от исходного состояния структуры общих сонных артерий, внутрисосудистого кровотока и центральной гемодинамики у больных артериальной гипертензией

Abstract

Aim. To study changes in structural and functional features of the common carotid arteries and central hemodynamic parameters under the influence of fosinopril at hypertensive patients depending on achieving target blood pressure.Material and methods. The study included 116 patients with essential hypertension. All patients underwent a general clinical study, an ultrasound scan of the common carotid arteries (CCA ) with the assessment of the structure and intravascular blood flow, and echocardiography with the definition of the parameters of central hemodynamic and intravascular, ambulatory blood pressure monitoring (ABPM) before the study and after 24 weeks of antihypertensive therapy angiotensin - converting enzyme fosinopril. Two groups of patients: the first group consisted of 74 people with the achievement of the targets of blood pressure (BP), the second 42 people who have not been achieved target BP levels.Results. In the first group there was a statistically significant decrease in the proportion of peripheral resistance, increased systolic index, distensibility coefficient of the common carotid arteries peak flow velocity. In the second group specific peripheral resistance was significantly increased, the thickness of the intima-media increased, decreased peak flow velocity.Conclusion. Effectiveness depends on fosinopril initial state total peripheral resistance, cardiac output, structural and functional features elastic arteries.