Хронічний вплив хлориду кадмію на ембріогенез щурів при ізольованому та комбінованому з сукцинатами цинку та міді внутрішньошлунковому введенні в експерименті

Abstract

The purpose of the study was to determine the degree of embryotoxicity of cadmium chloride at a dose of 2.0 mg/kg in isolated intragastric administration and to search for possible bioantagonists among zinc and copper succinates in combination with cadmium chloride in a chronic experiment in pregnant female rats. Materials and methods. The study was conducted on 64 pregnant female Wistar rats, which were distributed as follows: the first group – control; the second group – the isolated introduction of a solution of cadmium chloride at a dose of 2.0 mg/kg; the third group – the combined introduction of a solution of cadmium chloride at a dose of 2.0 mg/kg and zinc succinate at a dose of 5 mg/kg; the fourth group – the combined introduction of a solution of cadmium chloride at a dose of 2.0 mg/kg and copper succinate at a dose of 0.1 mg/kg. The possible negative effect of the studied substances on embryonic development was determined by the ability to increase the level of all types of embryonic mortality. Results and discussion. The calculation of the obtained results showed that the isolated chronic administration of cadmium chloride at a dose of 2.0 mg/kg has a pronounced embryotoxic effect on the number of embryos, total embryonic mortality, preimplantation and postimplantation embryonic mortality on the 13th and 19th day of embryogenesis in the experiment on rats. Cadmium and its compounds are one of the first eco-pollutants. The problem of embryotoxicity and fetotoxicity of microelements is of great practical importance, because a significant number of women work in industry and in hazardous production conditions and are often exposed to heavy metals, which is very dangerous for the fetus and offspring. Aspects of chronic influence on the course of embryogenesis of cadmium salts with microelements, which have bioanatagonistic properties in relation to the toxicity of heavy metals, have been little studied. Thus, an important area of morphological experimental research is the search for new possible bioantagonists of cadmium toxicity among trace elements that can affect dyslementosis, maintaining homeostasis, including during pregnancy. Conclusion. According to all criteria of embryotoxicity, isolated administration of cadmium has a pronounced embryotoxic effect, which is expressed in reducing the number of embryos in the manure and increasing all types of embryonic mortality. Combined administration of zinc or copper succinates with cadmium chloride has a modifying effect on the embryotoxicity of cadmium chloride in terms of basic embryotoxicity, and succinates themselves can be considered as potential bioantagonists of cadmium in chronic exposure in the experiment on rats