СРАВНИТЕЛЬНАЯ КЛИНИКО-ЛАБОРАТОРНАЯ И ИНСТРУМЕНТАЛЬНАЯ ОЦЕНКА ЭФФЕКТИВНОСТИ МОНО- И КОМБИНИРОВАННОЙ ТЕРАПИИ ТЕРАФЛЕКСОМ С ОСТЕНИЛОМ У БОЛЬНЫХ ПЕРВИЧНЫМ ОСТЕОАРТРИТОМ КОЛЕННЫХ СУСТАВОВ

Abstract

Objective: Comparative evaluation of the effectiveness of mono- and combined therapy of Teraflex with Ostenile in patients with early and developed primary knee osteoarthritis (OA). Methods: A comparative analysis and evaluation of the effectiveness of mono- and combined therapy of Teraflex with Ostenile in patients with primary knee OA (n=98) is presented. Depending on the evolutional stages of the disease progression, patients were divided into three groups: the first group – patients with stage I of OA (n=24); group II – patients with stage II of OA (n=39); group III – patients with stage III of OA (n=35). The duration of the study was 9 months (6 months of the therapy and 3 months of observations). Results: Statistically significant reduction in pain syndrome intensity and improvement in WOMAC index (all of its constituent parameters and total value), as well as clinical-laboratory indicators of OA activity were observed from the third month of the therapy and throughout the follow-up period, mainly in patients with early OA. Conclusion: Course usage of Teraflex in an effective daily dose in patients with primary knee OA (especially in the early stages of the disease) in both the form of monotherapy and in combined with Ostenile, positively affects all clinical symptoms of knee OA: quickly and effectively reduces pain syndrome, stiffness, significantly improves functional condition of patients and as much as possible limits the usage of non-steroidal anti-inflammatory drugs. Keywords: Primary osteoarthritis, knee joint, Teraflex, Ostenile, WOMAC index.