Влияние сенситизации и десенситизации капсаицин-чувствительных нейронов на образование эрозий в слизистой оболочке желудка, индуцированных индометацином, у крыс: роль глюкокортикоидных гормонов

Abstract

The aim of this work was to study the effect of sensitization and desensitization of capsaicin-sensitive afferent neurons (CSN) on the vulnerability of the rat gastric mucosa to the ulcerogenic action of indomethacin (35 mg/kg) and to evaluate the participation of glucocorticoids in this effect. Sensitization of CSN was caused by a single administration of capsaicin at the small doses, 0.1-10.0 mg/kg, desensitization was performed by administration of capsaicin in a total dose of 100 mg/kg (20, 30, 50 мг/кг, 2 weeks before indomethacin). Capsaicin (0.1-10.0 mg/kg) was administered 1 h before indomethacin. To evaluate the participation of corticosterone in the effects of capsaicin, the inhibitor of glucocorticoid synthesis metyrapone (30 mg/kg) was used. Desensitization of CSN with a large dose of capsaicin led to the aggravation of the ulcerogenic effect of indomethacin. The administration of capsaicin at the doses of 0.5-10.0 mg/kg, dose-dependently decreased the area of indomethacin-induced gastric erosions, as well as resulted in an increase in the blood level of corticosterone and glucose. Metyrapone administration prevented both the increase in the corticosterone level in response to capsaicin and gastroprotective effect of capsaicin (1 mg/kg). The results obtained suggest that glucocorticoids participate in realization of the gastroprotective effect of capsaicin