Abstract
Objective. To identify the relationship between polymorphisms of the angiotensin type 1 receptor gene (AGT2R1 A1166C) (rs 5186), endothelin-1 gene (LYS198ASN) (rs 5370), endothelial nitric oxide synthase gene NOS3 (C786T) (rs 2070744) and clinical, demographic, anthropological data in patients with coronary heart disease who underwent coronary artery bypass grafting under artificial circulation. Material and methods. All patients (123 people) underwent intraoperative venous blood sampling from a central venous catheter. Then, using the polymerase chain reaction method, there was performed an investigation of the genotypes of the gene polymorphisms of the angiotensin-1 receptor genes (AGTR1 A1166C), endothelin-1 (EDN1 Lys 198 Asn), endothelial nitric oxide synthase (NOS3 C786T), with further processing of the obtained results using the SNPStats online service. Results. The presence of T/C, T/T genotypes of the endothelial nitric oxide synthase gene polymorphism (NOS3 C786T) (rs 2070744) was detected predominantly in male patients. The correlation was found between female gender and the presence of the C/C genotype of the endothelial nitric oxide synthase polymorphism (NOS3 C786T) (rs 2070744). No correlations were found between the polymorphisms of the angiotensin type 1 receptor gene (AGTR1 A1166C) (rs 5186), the endothelin-1 gene (LYS198Asn) (rs 5370) and clinical and demographic (body mass index) indicators in the studied patients. Conclusion. The dominant model of the correlation between the endothelial nitric oxide synthase gene polymorphism (NOS3 C786T) (rs 2070744) and gender is statistically significant. The T/C-T/T genotype of the endothelial nitric oxide synthase gene polymorphism (NOS3 C786T) (rs 2070744) is predominant in male patients, while the C/C genotype is predominant in female patients.
Published Version
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