АБ УДЗЕЛЕ АРГІНАЗЫ ПЕЧАНІ І КЛЕТАК КУПФЕРА Ў РЭГУЛЯЦЫІ ЗМЕСТУ ХАЛЕСТЭРЫНУ Ў ПЕЧАНІ І ЛІПАПРАТЭІНАЎ КРЫВІ, УЗРОЎНЯ ЁДЗМЯШЧАЛЬНЫХ ГАРМОНАЎ ШЧЫТАПАДОБНАЙ ЗАЛОЗЫ І ТЭМПЕРАТУРЫ ЦЕЛА Ў ПАЦУКОЎ З ЭКСПЕРЫМЕНТАЛЬНЫМ ПЕРЫТАНІТАМ

Abstract

Despite the successes of modern surgery, the achievements of asepsis and antisepsis, the rather wide possibilities of antibacterial, infusion and detoxifica-tion therapy, the incidence of peritonitis and mortality from it remain at a high level. The aim of the study was to elucidate the significance of the activity of liver arginase and Kupffer cells in the regulation of total cholesterol in the liver and blood lipoproteins, the level of iodine-containing thyroid hormones and body temperature in rats with experimental peritonitis. It has been established that under conditions of experimental peritonitis in rats, the activity of liver arginase decreases, the content of NO3–/NO2– increases and the level of iodine-containing thyroid hormones in the blood decreases, secondary atherogenic dyslipoproteinemia develops. A decrease in the activity of Kupffer cells in peritonitis is accompanied by an increase in the level of trii-odothyronine in the blood, a less pronounced decrease in the activity of liver arginase and a weakening of the development of characteristic changes in the content of total cholesterol in the liver, lipoprotein cholesterol in the blood and prevents the development of secondary dyslipoproteinemia. Depression of liv-er arginase in conditions of peritonitis aggravates changes in the content of to-tal cholesterol in blood and liver lipoproteins, triiodothyronine in the blood and contributes to the development of secondary dyslipoproteinemia.