On the significance of the activity of liver arginase and Kupffer cells in the development of secondary atherogenic dyslipidemia and the formation of thyroid status in rats with experimental peritonitis

Abstract

Peritonitis is one of the most severe complications of various diseases and injuries of the abdominal organs. The diagnosis of peritonitis in a general sense implies any form and severity of inflammation of the peritoneum. Currently, the problem of peritonitis remains actual, despite the achievements of scientific and technological progress. So, despite the successes of modern surgery, the achievements of asepsis and antiseptics, the rather wide possibilities of antibacterial, infusion and detoxification therapy, the incidence of peritonitis and mortality from it remain at a high level. The aim of the study was to elucidate the significance of the activity of liver arginase and Kupffer cells in the development of secondary atherogenic dyslipidemia and the formation of thyroid status in rats with experimental peritonitis. It has been established that under conditions of experimental peritonitis in rats, the activity of liver arginase decreases, the content of NO3 – /NO2 – increases and the level of iodine-containing thyroid hormones in the blood decreases, secondary atherogenic dyslipoproteinemia develops. Liver arginase and Kupffer cells are involved in changes in the content of total cholesterol in the liver, total cholesterol, lipoprotein cholesterol, the level of iodine-containing hormones in the blood and body temperature in peritonitis. A decrease in the activity of Kupffer cells in peritonitis is accompanied by an increase in the level of triiodothyronine in the blood, a less pronounced decrease in the activity of liver arginase and a weakening of the development of characteristic changes in the content of total cholesterol in the liver, lipoprotein cholesterol in the blood and prevents the development of secondary dyslipoproteinemia. Depression of liver arginase in conditions of peritonitis aggravates changes in the content of total cholesterol in blood and liver lipoproteins, triiodothyronine in the blood and contributes to the development of secondary dyslipoproteinemia.