Magnetic ZnFe2O4 Nanoparticles Research Articles

Mesoporous g-C3N4/ZnFe2O4/TCPP nanocomposite for selective liquid-phase oxidation of alcohols to aldehydes under visible light irradiation

This study provides a viable strategy for the production of aromatic benzaldehydes by a three-component magnetic recoverable photocatalyst. The novel photocatalyst was fabricated by modification of Graphitic carbon nitride (g-C3N4) using ZnFe2O4 magnetic nanoparticles and Tetrakis(4-carboxyphenyl)porphyrin (TCPP) and labeled as CFP where C is the carbonic substrate, F shows the magnetic component and P demonstrated TCPP porphyrin. The optimized CFP photocatalyst demonstrated approximately 96 % conversion and 99 % selectivity for the oxidation of benzyl alcohol to benzaldehyde. The photocatalytic reaction carried out in the presence of acetonitrile and H2O2 as solvent and oxidant under LED lamp (15 W) irradiation. The results reveal that the values of conversion and selectivity of various types of benzylic alcohols are attributed to the aromaticity and position of substituents on the benzene ring. The reusability of CFP photocatalyst was investigated up to the fourth cycle, and it revealed any significant loss of photocatalytic oxidation activity, which is related to high structural stability of photocatalyst.

Nonradical pathway dominated activation of peroxymonosulfate by ZnFe2O4/C composites to eliminate tetracycline hydrochloride: Insight into the cycle of Zn/Fe and electron transfer

Magnetic ZnFe2O4 nanoparticles show promising as heterogeneous catalysts in peroxymonosulfate (PMS) activation because of their ease of separation and good reusability. However, the low catalytic activity and easy agglomeration in clusters or clumps limit the application of ZnFe2O4 nanoparticles. Herein, ZnFe2O4 nanoparticles embedding into carbon substrate are prepared. Owing to the anchoring effect of carbon substrate and the improved electron transfer for ZnFe2O4 nanoparticles, the as-prepared magnetic ZnFe2O4/C composites exhibit efficiently catalytic activity in PMS activation, in which 92.0% of tetracycline hydrochloride (TC) can be eliminated. Moreover, the composites show a wide pH adaptation range (3.04–10.99) and good stability. The catalytic oxidation of TC is mainly based on the nonradical pathways, including contributions of 1O2 and electron transport. The high performance of ZnFe2O4/C in PMS activation is mainly attributed to the accelerated redox cycles of Fe3+/Fe2+ and Zn2+/Zn+ and the improved electron transfer. Three possible TC degradation pathways were proposed, and the biotoxicity assessment results further confirm the high efficiency of the ZnFe2O4/C/PMS system. This work provides a simple strategy for the preparation of magnetic ZnFe2O4/C heterogeneous catalyst and a new insight into PMS activation, which promotes the application of spinel nanomaterials in environmental remediation.

Facile preparation of a cost-effective platform based on ZnFe2O4 nanomaterials for electrochemical cell detection

Circulating tumor cells (CTCs) are important tumor markers that indicate early metastasis, tumor recurrence, and treatment efficacy. To identify and separate these cells from the blood, new nanomaterials need to be developed. The present study explored the potential application of ZnFe2O4 magnetic nanoparticles in capturing CTCs with cell surface markers. Folic acid was coupled to l-cysteine-capped ZnFe2O4 nanoparticles (ZC) to provide binding sites on ZnFe2O4 nanoparticles for the recognition of folate bioreceptors, which are highly expressed in MCF-7 breast cancer cells. The cytotoxicity of ZnFe2O4 nanoparticles and ZC against MCF-7 was analyzed with the MTT assay. After 24 h of incubation, there were IC50 values of 702.6 and 805.5 µg/mL for ZnFe2O4 and ZC, respectively. However, after 48 h of incubation, IC50 values of ZnFe2O4 and ZC were reduced to 267.3 and 389.7 µg/mL, respectively. The cell quantification was conducted with magnetically collected cells placed on a glassy carbon electrode, and the differential pulse voltammetry (DPV) responses were analyzed. This cost-effective ZnFe2O4-based biosensing platform allowed cancer cell detection with a limit of detection of 3 cells/mL, ranging from 25 to 104 cells/mL. In future, these functionalized zinc ferrites may be used in electrochemical cell detection and targeted cancer therapy.

Arabic Gum-Grafted-Hydrolyzed Polyacrylonitrile@ZnFe2O4 as a Magnetic Adsorbent for Remediation of Levofloxacin Antibiotic from Aqueous Solutions.

The Arabic gum-grafted-hydrolyzed polyacrylonitrile/ZnFe2O4 (AG-g-HPAN@ZnFe2O4) as organic/inorganic adsorbent was obtained in three steps using grafted PAN onto Arabic gum in the presence of ZnFe2O4 magnetic nanoparticles and then hydrolysis by alkaline solution. Fourier transform infrared (FT-IR), energy-dispersive X-ray analysis (EDX), field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), thermogravimetric analysis (TGA), vibrating sample magnetometer (VSM), and the Brunauer-Emmett-Teller (BET) analysis analyses were used to characterize the chemical, morphological, thermal, magnetic, and textural properties of the hydrogel nanocomposite. The obtained result demonstrated that the AG-g-HPAN@ZnFe2O4 adsorbent showed acceptable thermal stability with 58% char yields and superparamagnetic property with magnetic saturation (Ms) of 24 emu g-1. The XRD pattern showed that the semicrystalline structure with the presence of ZnFe2O4 has distinct peaks which displayed that the addition of zinc ferrite nanospheres to amorphous AG-g-HPAN increased its crystallinity. The AG-g-HPAN@ZnFe2O4 surface morphology exhibits uniform dispersion of zinc ferrite nanospheres throughout the smooth surface of the hydrogel matrix, and its BET surface area was measured at 6.86 m2/g, which was higher than that of AG-g-HPAN as a result of zinc ferrite nanosphere incorporation. The adsorption effectiveness of AG-g-HPAN@ZnFe2O4 for eliminating a quinolone antibiotic (levofloxacin) from aqueous solutions was investigated. The effectiveness of adsorption was assessed under several experimental conditions, including solution pH (2-10), adsorbent dose (0.0015-0.02 g) contact duration (10-60 min), and initial concentration (50-500 mg/L). The maximum adsorption capacity (Q max) of the produced adsorbent for levofloxacin was found to be 1428.57 mg/g (at 298 k), and the experimental adsorption data were well explained by the Freundlich isotherm model. The pseudo-second-order model satisfactorily described the adsorption kinetic data. The levofloxacin was mostly adsorbed onto the AG-g-HPAN@ZnFe2O4 adsorbent via electrostatic contact and hydrogen bonding. Adsorption-desorption studies demonstrated that the adsorbent could be efficiently recovered and reused after four consecutive runs with no significant loss in adsorption performance.

ZnFe2O4@SiO2‐ascorbic acid: Green, magnetic, and versatile catalyst for the synthesis of chromeno[2,3‐d] pyrimidine‐8‐amine and quinazoline derivatives

AbstractIn this research project, silica‐modified ZnFe2O4 magnetic nanoparticles were prepared in a simple, short, and straightforward way. Subsequently, an efficient catalyst through immobilization of ascorbic acid on the surface of silica‐coated ZnFe2O4 nanoparticles has been produced. The physical and chemical properties of ZnFe2O4@SiO2‐ascorbic acid were considered by X‐ray diffraction (XRD), Fourier transform infrared spectroscopy (FT‐IR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), Energy‐dispersive X‐ray spectroscopy (EDS), and vibrating sample magnetometer (VSM) analyses. The catalytic activity of described magnetic nanocatalyst was checked out for the synthesis of chromeno[2,3‐d] pyrimidine‐8‐amine and quinazolinone derivatives. The described catalyst was recovered and reused for five continuous cycles without considerable change in its catalytic activity.

Tunable and broadband high-performance microwave absorption of ZnFe2O4 nanoparticles decorated Ti3C2Tx MXene composites

MXene, especially Ti3C2Tx, is attracting extensive attention as an absorbing material owing to its strong dielectric loss and tunable structure. Nevertheless, extremely high conductivity and non-magnetic loss mechanism limit the absorbing intensity and effective absorption bandwidth (EAB). Herein, the magnetic ZnFe2O4 nanoparticles decorated Ti3C2Tx MXene composite is designed and synthesized by using a facile in-situ solvothermal method. The novel ZnFe2O4@Ti3C2Tx-2 (1:2) composite shows an optimal reflection loss of −60.94 dB and a wide EAB of 6.08 GHz at a matching thickness of only 1.75 mm. The mechanism analysis reveals that the synergetic electromagnetic loss effect, interfacial polarization, dipole polarization, and laminated structure contribute to improving the microwave absorption (MA) performance. Furthermore, to confirm the use capability of the ZnFe2O4@Ti3C2Tx sample coatings in practical applications, the radar cross-section (RCS) reduction performance has been proved through using computer simulation technology (CST). With the detection theta of 0°, the ZnFe2O4@Ti3C2Tx-2 sample coating possesses the largest RCS reduction value of 22.83 dB. This work lays the foundation for the rational design of high-performance absorbing materials.

Ultrasensitive detection of protein biomarkers by MALDI-TOF mass spectrometry based on ZnFe2O4 nanoparticles and mass tagging signal amplification

A facile MALDI-TOF mass spectrometric platform for quantitative analysis of protein biomarkers was developed based on magnetic ZnFe2O4 nanoparticles and mass tagging signal amplification. In this platform, magnetic ZnFe2O4 nanoparticles functionalized with an aptamer of the biomarker of interest was used to magnetically separate silica nanoparticles modified with another aptamer of the target biomarker and a barcoding peptide from solution phase in the presence of the biomarker of interest. After the silica nanoparticles were dissolved by KHF2, the released barcoding peptide was detected by MALDI-TOF mass spectrometry with magnetic ZnFe2O4 nanoparticles used as assisting matrix of laser desorption ionization. Since the mass spectral intensity of the barcoding peptide is directly related to the concentration of the target biomarker, the proposed platform can be applied to the quantification of the target biomarker in complex biological samples. The effectiveness of the proposed platform was tested on the detection of carcinoembryonic antigen (CEA) in serum. Experimental results revealed that the proposed platform could achieve quite reliable quantitative results for CEA in human serum samples with accuracy comparable to a commercial CEA ELISA Kit. Its limit of detection and limit of quantification for CEA were estimated to be 0.6 × 10−3 and 1.8 × 10−3 ng/mL, respectively, considerably lower than the corresponding values reported in literature. Due to its features of simplicity in design, extremely low background signal, high sensitivity and selectivity, the proposed method can be further developed to be a competitive alternative for the quantification of CEA and other protein biomarkers as well.

Selective extraction of malathion from biological fluids by molecularly imprinted polymer coated on spinel ZnFe2O4 magnetic nanoparticles based on green synthesis

ABSTRACT The design, processing, and characterization of a novel magnetic molecularly imprinted polymer (MIP) have been accomplished and applied to extract malathion from plasma samples. FTIR, X-ray diffraction, SEM, and vibrating sample magnetometric (VSM) methods were used to characterize the MIP particles. The selectivity of the MIP for the extraction of malathion was examined in the presence of some similar organophosphorus pesticides, including fenitrothion, fosalon, dichlorvos, dimethoate, ethion, and diazinon. Results revealed that Langmuir constant, the limit of detection, and maximum enrichment capacity for malathion are 876 μg L −1, 7 µg L −1, and 5, respectively.

Achieving excellent electromagnetic wave absorption of ZnFe2O4@CNT/polyvinylidene fluoride flexible composite membranes by adjusting processing conditions

The magnetic ZnFe2O4 nanoparticles were synthesized and combined with carbon nanotubes (CNTs) to form a unique tangled structure (ZnFe2O4@CNT), and then used as wave absorbing functional nanofillers of polyvinylidene fluoride (PVDF) matrix. The effects of ZnFe2O4@CNT functional nanofillers on the microstructure, crystallization behavior and electromagnetic wave absorption properties of PVDF were studied. The ZnFe2O4@CNT/PVDF composite membranes containing 7 wt% nanofillers presented an optimal reflection loss of −54.5 dB with a sample thickness of 2.4 mm when the processing temperature was 60 °C. If the processing temperature of 150 °C was adopted, the composite membranes with a thickness of only 2.0 mm surprisingly achieved an effective absorption of the whole X-band. The combination of interfacial polarization, polarization relaxation loss, dipole polarization, conductivity loss, and ferromagnetic resonance loss promoted the excellent microwave energy dissipation capacity of ZnFe2O4@CNT/PVDF system.

Peroxidase mimetic activity of porphyrin modified ZnFe2O4/reduced graphene oxide and its application for colorimetric detection of H2O2 and glutathione

Artificial nanoenzymes which can overcome some drawbacks of natural enzymes is a challenging topic in the biosensor field. Herein, we demonstrated 5, 10, 15, 20-tetrakis (4-carboxylpheyl)-porphyrin modified magnetic ZnFe2O4 nanoparticles loaded on the surface of reduced graphene oxide (Por-ZnFe2O4/rGO), which exhibited intrinsic peroxidase-like activity and rapidly oxidized the peroxidase substrate 3, 3′, 5, 5′-tetramethylbenzidine (TMB) into a blue product (OxTMB) distinguished by naked eyes. Interestingly, by comparative study of different nanomaterials ZnFe2O4 nanoparticles, ZnFe2O4/rGO and Por-ZnFe2O4, Por-ZnFe2O4/rGO was proved to possess the highest peroxidase-like activity. Electron spin resonance (ESR) verified the catalytic activity of Por-ZnFe2O4/rGO for H2O2 was due to hydroxyl radical from decomposition of H2O2. Temperature and pH strongly affected the peroxidase-like activity of Por-ZnFe2O4/rGO nanocomposites. Under optimal conditions (pH = 4, 40 °C), the constructed sensor based on the catalytic activity of the Por-ZnFe2O4/rGO could be conveniently used for colorimetric detection of H2O2 in the range of 0.7–30 μM with the detection limit of 0.54 μM. Moreover, the colorimetric sensor based on Por-ZnFe2O4/rGO exhibited a good linear response to glutathione (GHS) in the range of 2–40 μM with a low detection limit of 0.76 μM. The detection of GHS can be easily realized through the obvious color change by naked eyes without any complicated instrumentation.

The effect of basic pH on the elaboration of ZnFe2O4 nanoparticles by co-precipitation method: Structural, magnetic and hyperthermia characterization

Abstract The present study reports on the synthesis and characterization of zinc iron oxide ZnFe2O4 magnetic nanoparticles (MNPs) using the co-precipitation method. Particular attention has been paid to study the influence of the pH in the range between 9 and 12 on both structural and magnetic properties of the MNPs. X-ray diffraction analysis shows the presence of a single phase of partially invers cubic spinel ferrites ZnFe2O4. Transmission Electron Microscopy (TEM) analysis shows the formation of highly crystalline MNPs and a change of shape from a polyhedral shape at pH 9 to a spherical-like shape for a pH 12. The MNPs mean-size increases from 19 to 33 nm with the increase of pH value. The ZnFe2O4 MNPs are superparamagnetic at room temperature displaying a magnetization of 12 emu/g at the maximum applied static magnetic field. The heating efficiency of spherical zinc ferrites MNPs was evaluated for hyperthermia application and displays a linear increment of the specific absorption rate (SAR) up to 125 (W/gFe) under an alternating magnetic field ranging from 5 to 65 kA/m and operating at a frequency of 355 kHz.

Stabilization of Magnetic Ferrite Nanostructures with Cellulose Derived From Biomass for the Abatement of Environmental Pollution

Abstract Magnetic ZnFe2O4 nanoparticles were stabilized using biomass derived cellulose to fabricate high performance cellulose based nanocomposites. The synthesized nanocomposites were well characterized using FT-IR, Powder XRD and TEM analysis. TEM images revealed the decoration of ZnFe2O4 nanoparticles onto the surface of cellulose. The synthesized nanocomposites displayed enhanced catalytic activity for the photocatalytic degradation of toxic remazol black 5 dye in comparison to the pristine ZnFe2O4 nanoparticles and cellulose. Furthermore, the magnetically retrievable nature of the nanocomposites facilitated the easy recyclability and reusability of the nanocomposites. The present work promotes the use of biomass derived materials to prepare inorganic/organic hybrid materials for mitigation of environmental pollution.

Glycol stabilized magnetic nanoparticles for photocatalytic degradation of xylenol orange

In this work, we have successfully prepared ZnFe2O4 magnetic nanoparticles as photocatalysts via co-precipitation method using triethylene glycol as a stabilizing agent. The resultant nanoparticles were annealed at 400 °C and then acid etched and surface functionalized with 3-(triethoxysilyl) propyl amine (APTES). Fourier transform infrared (FTIR) spectroscopy and x-ray diffraction (XRD) analysis were used to characterize these magnetic photocatalysts. XRD patterns revealed that the size of annealed and functionalized ZnFe2O4 nanoparticles falls in the range of 23.3 and 13.9 nm, respectively. The optical band gaps of the magnetic photocatalysts were calculated from UV–Visible absorption spectra using Tauc plots. The band gap of the ZnFe2O4 photocatalyst in acidic and basic medium was 2.47 and 2.7 eV, respectively. The performance of the magnetic photocatalysts was evaluated for xylenol orange (XO) degradation. The degradation rates of XO dye for the blank, annealed and functionalized photocatalysts at pH = 4 were 76%, 85%, and 90%, respectively. In addition, the influence of important parameters such as contact time, pH, catalyst, and dye dose were also investigated for all the three photocatalysts. The applied kinetics models demonstrated that the degradation followed pseudo 1st order.

Synthesis of 3-amino-5-methyl-[1,1'-biaryl]-2,4-dicarbonitriles using ZnFe2O4 magnetic nanoparticles

This work studies an efficient, one-pot pseudo multi-component synthesis of 3-amino-5-methyl-[1, 1'-biaryl]-2, 4-dicarbonitriles. This reaction performed under solvent free conditions in the presence of ZnFe2O4 magnetic nanoparticles. The ZnFe2O4 nanoparticles were prepared by an eco-friendly hydrothermal method

Superparamagnetic behaviour of zinc ferrite obtained by the microwave assisted method

Magnetic ZnFe2O4 nanoparticles with magnetization saturation of 12.1 emu/g were synthesized through hydrothermal microwave method at 140 °C for 32 min. These compound is being tested in magnetic hyperthermia a promising therapeutic cancer treatment, which causes lysis of tumor cells by heating magnetic nanoparticles through an external magnetic field. X-ray diffraction reveals a single-phase ZnFe2O4 nanoparticles with well-defined structure while Raman spectroscopy reveals that at 32 min of soaking time provides the energy crystallization, causing anisotropy in the structural growth at short range causing a certain degree of order in the crystal lattice. Morphology of the powders was investigated by transmission electronic microscopy (HRTEM) which showed particle sizes with 10–25 nm of diameter being an important factor for application in magneto-hyperthermia. Magnetic parameters analyzed by means of a vibrating-sample magnetometer unit showed that these nanoparticles have great potential in magneto-hyperthermia application.

A novel microfluidic paper-based colorimetric sensor based on molecularly imprinted polymer membranes for highly selective and sensitive detection of bisphenol A

A novel microfluidic paper-based colorimetric sensor for the detection of bisphenol A (BPA) was developed based on the intrinsic peroxidase activity of ZnFe2O4 magnetic nanoparticles (ZnFe2O4 MNPs) and the adsorption capacity of molecularly imprinted polymer (MIP) membranes. In the process, ZnFe2O4 MNPs and cellulose fibers in paper were wrapped by MIP membranes (ZnFe2O4@MIP membranes) successfully. Novel MIP membranes for the recognition of BPA were prepared in polar solvent using acrylamide as the functional monomer and BPA as the template by bulk polymerization, which resulted in a new type of BPA imprinted polymer membranes. Adsorption isotherms model of MIP membranes was employed to describe the isotherms, and maximum adsorption capacity was evaluated. In the presence of 3,3′,5,5′-tetramethylbenzidine (TMB), the as-prepared ZnFe2O4 MNPs peroxidase mimetics was used to catalyze chromogenic reactions and showed the color with respective intensity. Under optimized conditions, the grey intensity was found to be proportional to the BPA concentrations in the range of 10 nM–1000nM (R2=0.9945) with a detection limit of 6.18nM. With the advantages of highly reproducible response, good selectivity and excellent regeneration, the colorimetric sensor holds great potential for portable detection of targets in environmental monitoring, security inspection and complicated matrices.

Upconversion ratiometric fluorescence and colorimetric dual-readout assay for uric acid

A new upconversion colorimetric and ratiometric fluorescence detection method for uric acid (UA) has been designed. Yb3+, Er3+ and Tm3+ co-doped NaYF4 nanoparticles (UCNPs) was synthesized. The co-doped NaYF4 nanoparticles, emit upconversion fluorescence with four typical emission peaks centered at 490nm, 557nm, 670nm and 705nm under the 980nm near-infrared (NIR) irradiation. The ZnFe2O4 magnetic nanoparticles (MNPs) possessing excellent peroxidase-like activity was prepared and used to catalyze oxidation the coupling of N-ethyl-N-(3-sulfopropyl)-3-methylaniline sodium salt (TOPS) and 4-amino-antipyrine (4-AAP) in the presence of H2O2 to form purple products (compound 1) which has a characteristic absorption peak located at 550nm. The upconversion fluorescence at 557nm was quenched by the compound 1 while the upconversion emission at 705nm was essentially unchanged, the fluorescence ratio ((I557/I705)0/(I557/I705)) is positively proportional to UA concentration in existence of uricase. More importantly, colorimetric signal can be easily observed and applied to directly distinguish the concentration of UA by the naked eye. Under the optimized conditions, the linear range of colorimetric and ratiometric fluorescence sensing towards UA was 0.01–1mM, the detection limits were as low as 5.79μM and 2.86μM (S/N=3), respectively. The proposed method has been successfully applied to the analysis of UA in human serum. These results indicate that the colorimetric and ratiometric fluorescence dual-readout assay method has great potential for applications in physiological and pathological diagnosis.

A novel 5-fluorouracile anticancer drug sensor based on ZnFe2O4 magnetic nanoparticles ionic liquids carbon paste electrode

A carbon paste electrode modified in situ with ZnFe2O4 magnetic nanoparticles (ZnFe2O4/MNPs) and 1,3-dipropylimidazolium bromide ionic liquid was developed for the determination of 5-fluorouracile (5-FU) in drug samples. The electrochemical behavior of 5-FU was investigated employing linear sweep voltammetry (LSV), square wave voltammety (SWV), chronoamperometry (CA) and electrochemical impedance spectroscopy (EIS). ZnFe2O4/MNPs synthesized by co-precipitation method and characterized with different methods such as energy dispersive X-ray analysis (EDAX), X-ray powder diffraction (XRD) and transmission electron microscopy (TEM). After optimization of experimental conditions employing the novel sensor at pH 7.0, the electro-oxidation peak currents for 5-FU was found to vary linearly with its concentrations in the range of 0.1–1400μM using SWV method. The ZnFe2O4/MNPs ionic liquids carbon paste electrode (ZnFe2O4/MNPs/IL/CPE) showed several advantages, such as a high sensitivity in trace analysis, good detection limits and excellent reproducibility. Furthermore, the ZnFe2O4/MNPs/IL/CPE was successfully applied for the analysis of 5-FU in pharmaceutical and urine samples.

Innovative one pot synthesis method of the magnetic zinc ferrite nanoparticles with a superior adsorption performance

A convenient strategy for preparing a single phase of crystalline zinc ferrite nanoparticles assisted by microwave heating approach is reported. This technique involves a one-pot solid state reaction of self-combustion using glycine as fuel, ammonium nitrate as driving agent and metal nitrates as reactants in a designed reaction set-up. The set-up has been manufactured from an alumina crucible encircled by a jacket of CuO as microwave absorbing layer. This work-piece absorbs microwaves and creates the calcination conditions without any external heat source. The reactions were operated with a power of 900W for 20min. The results revealed the successful synthesis of magnetic ZnFe2O4 nanoparticles with the average particle size of 32nm with a Langmuir surface area of 82.13m2g−1. The adsorption performance of the as-prepared product for water purification from colored pollutants was also discussed in detail.

Preparation of ZnFe2O4–chitosan-doxorubicin hydrochloride nanoparticles and investigation of their hyperthermic heat-generating characteristics

In this study, the structural morphology and magnetic effects of magnetic ZnFe2O4 nanoparticles loaded with the cancer-fighting drug doxorubicin hydrochloride (DOX-HCl) were investigated. These nanoparticles have been found to have potential biomedical applications in targeted drug-delivery systems. The zinc ferrite nanoparticles were prepared by a chemical coprecipitation method and coated with chitosan. The nanoparticles were loaded with DOX-HCl and their surfaces improved by folic acid, which can be activated to target specific cancer cells. The specific absorption rate (SAR) values of the ZnFe2O4–chitosan–DOX-HCl nanoparticles were investigated at a frequency of 200kHz and 1.5kA/m amplitude in order to obtain Brownian relaxation time parameters. X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM), vibrating sample magnetometry (VSM), and ultraviolet–visible spectrophotometry (UV–vis) were used to characterize the bulk properties of these nanoparticles. In addition, the impact of the nanoparticles under an alternating current (AC) magnetic field and their heat-generation ability were investigated using an experimental setup. The average nanoparticle size was found to be 8.5nm. Magnetic hysteresis loops confirmed the superparamagnetism of the nanoparticles. The saturation magnetization was 6emu/g. UV–vis was used to measure the amount of drug loaded onto the nanoparticles. The amount of drug absorption was significantly higher after 12h, totaling 75%. The specific absorption rate parameter was 80.66W/g, and the Brownian relaxation time was 188×10−9s.