Zn Intake Research Articles

A Mendelian randomization analysis of inflammatory skin disease risk due to mineral deficiencies.

Mineral deficiencies, such as iron (Fe), zinc (Zn), and selenium (Se), play crucial roles in inflammation and immune responses and are linked to chronic inflammatory skin diseases. This study used genome-wide association study (GWAS) data and Mendelian randomization (MR) to investigate the genetic causality among serum levels of five minerals (Fe, Cu, Zn, Se, Ca), three iron metabolism indicators (TSAT, TIBC, ferritin), and three chronic inflammatory skin diseases [psoriasis (PS), atopic dermatitis (AD), acne vulgaris (AV)]. Two-sample MR analyses using the "TwoSample MR" package in R were conducted with aggregate outcome data from the FinnGen database. The inverse-variance-weighted (IVW) method was applied to assess causal relationships between mineral levels and disease outcomes. Robustness was examined via heterogeneity and pleiotropy tests. IVW analysis showed significant association between blood transferrin saturation (TSAT) and PS (p = 0.004, OR = 1.18). Serum Zn and Se levels showed inverse correlation with AD (p = 0.039, OR = 0.92). However, due to limited SNPs, robustness was reduced. TSAT is genetically linked to PS, highlighting iron homeostasis in disease development. Zn and Se intake may reduce AD risk.

17 Effects of trace mineral source on dry matter digestibility of silage and mineral absorption

Abstract Copper, manganese, and zinc when coming from highly soluble sources in the rumen can strongly bind to diet fiber, which reduces it intestinal absorption and DM digestibility. Thus, the objective of this study was to evaluate the digestibility of dry matter and the apparent absorption of Cu, Mn, and Zn depending on different sources of these trace minerals. Four ruminally cannulated crossbred steers [body weight (BW = 560 ± 35 kg)] were used in a 4 × 4 Latin square design and offered corn silage ad libitum, and mineral supplement for four 21-d periods (14-d adaptation and 7-d data collection). Treatments assigned were: 1) Control (No Cu, Mn, and Zn); 2) Cu, Mn, and Zn-sulfate; 3) Cu, Mn, and Zn-organic; and 4) Cu, Mn, and Zn-hydroxychloride. In each period, two dry matter intake measurements and two total feces collections were carried out for 24 h. Thus, the digestibility of dry matter (DMd) and the apparent absorption (aA = trace minerals intake - trace minerals in feces/trace minerals intake) of Cu, Mn, and Zn were calculated. Data were subjected to analysis of variance (P < 0.05), and when significant, a multiple comparison test was performed (SNK test). No treatment x animal x period interactions were observed (P ≥ 0.05). The greatest DM digestibility was in the diets with Cu, Mn, and Zn-hydroxychloride and Cu, Mn, and Zn-organic, and the least DMd were Cu, Mn, and Zn-sulfate and control diet (P < 0.05), respectively 588, 575, 468 e, 449 g/kg (Table 1). Copper apparent absorption was greater (P < 0.05) in steers receiving Cu-hydroxychloride (0.14) and Cu-organic (0.12) and was equal (P ≥ 0.05) between those receiving Cu-sulfate (0.05) and those not receiving (-0.006) supplemental Cu. The sources did not affect (P ≥ 0.05) manganese aA, and the absorption of Mn was greater (P < 0.05) in steers receiving Mn than those not receiving. Diets with Zn-hydroxychloride (0.16) and Zn-organic (0.12) had greater (P < 0.05) aA than diet with Zn-sulfate (0.01), and steers that did not receive supplemental zinc (-0.10) had the least (P < 0.05) zinc aA. Low ruminal solubility trace minerals sources result in greater DM digestibility. Hydroxychloride and organic are more absorbable than Cu and Zn sulfates. Non-supplementation resulted in a net loss of Cu, Mn, and Zn, regardless of the type of trace minerals source.

Identification of dietary patterns and their relationship with zinc intake in male and female workers

Objectives Deficiency of zinc, an essential trace element in the body, adversely affects taste, wound healing, and immunity. This study aimed to identify the dietary patterns of male and female workers using factor analysis and clarify the relationship between dietary patterns and zinc intake.Methods The participants were 395 municipal employees (193 men and 202 women) in Northern Kyushu aged 19-71 years. To obtain the dietary intake data, participants were asked to complete a lifestyle and health questionnaire and brief self-administered dietary history questionnaire. Zn intake was evaluated per 1,000 kcal (mg/1,000 kcal). The values were adjusted for energy using the density method, and multiple regression analysis was performed.Results Three dietary patterns were identified for each participant. Among men, "main and side dish type pattern" characterized by higher intakes of potatoes, legumes, vegetables, seafood, meat, and low for cereals, "snack type pattern" characterized by higher intakes of sweets and coffee, and "Mediterranean diet pattern" characterized by higher intakes of bread, pasta, fruits, eggs, and milk, and low for miso soup and rice were identified. For women, a "vegetarian diet type pattern" characterized by higher intakes of beans, vegetables, mushrooms, and seaweed, "main and side dish type pattern" characterized by low intake of rice, and "dinner-time drinking pattern" characterized by higher intakes of alcoholic beverages were identified. Zinc intake was positively associated with the "main and side dish type pattern" and "Mediterranean diet pattern" in men and "vegetarian diet" and "main and side dish type pattern" in women. Additionally, zinc intake was negatively associated with the "dinner-time drinking pattern" among women.Conclusion Despite adjusting for age, BMI, marriage, occupation, smoking habits, and exercise habits, the "main and side dish type pattern" and "Mediterranean diet pattern" were positively correlated with zinc intake in men and the "vegetarian diet" and "main and side dish type pattern" in women. The data suggest awareness of the dietary patterns that are conducive to ensuring zinc intake.

Dietary Zinc Intake and the Association of Insulin Level and HOMA-IR with Telomere Shortening in Mexican Children.

The relationship between dietary zinc (Zn) intake, metabolic diseases, and telomere length has been little explored in the children population. This observational cross-sectional study assesses the association between obesity (OB), cardiometabolic traits, telomere length, and dietary Zn intake in children with normal weight (NW) and OB from Mexico City. Anthropometric data, blood pressure, biochemical measurements, the homeostatic model assessment of insulin resistance (HOMA-IR) and leucocyte telomere length (determined by quantitative-PCR) were analyzed in 171 children with NW and 172 with OB. Furthermore, dietary Zn intake was evaluated in 117 children NW and 120 with OB. Telomere shortening was associated with fasting plasma insulin (FPI) and HOMA-IR in NW (beta coefficient [β]FPI = -0.022 ± 0.008, p = 0.009; βHOMA-IR = -0.096 ± 0.040, p = 0.020) and OB (βFPI = -0.007 ± 0.002,p = 0.003; βHOMA-IR = -0.034 ± 0.012,p = 0.005) children. Dietary Zn intake resulted negatively associated with FPI (β = -2.418 ± 0.764, p = 0.002) and HOMA-IR (β = -0.399 ± 0.014, p = 0.009) in children with OB. Then, in children with OB, the association between FPI, HOMA-IR, and telomere shortening was evaluated separately in groups of low, medium, and high dietary Zn intake (according to tertiles). The association between FPI, HOMA-IR, and telomere shortening was not significant in the high Zn intake group (PFPI = 0.633; PHOMA-IR = 0.567). Our results suggest that a high Zn intake may ameliorate the telomere shortening related to high FPI and HOMA-IR.

Arsenic and zinc concentrations in wheat grains under soil zinc application and arsenic‐contaminated irrigation

AbstractAbove‐permissible levels of arsenic (As) in irrigation water lead to toxic levels in wheat grains, increasing health risks for humans. In this study, two zinc (Zn)‐biofortified wheat (Triticum aestivum L.) cultivars (Akbar‐2019 and Zincol‐2016) were grown in pots with two Zn application rates (0 and 8 mg Zn kg−1) and three levels of As in irrigation water (distilled‐water control, 100 and 1000 µg As L−1). Irrigation with As‐contaminated water decreased dry matter yields, concentrations of grain phosphorus (P) and Zn, and estimated daily intake (EDI) of Zn. Conversely, it increased grain As concentration and As EDI. Soil Zn application mitigated the negative effects of As on dry matter yields of both cultivars while simultaneously enhancing grain Zn concentration and Zn EDI. On average, Zn application increased grain Zn concentration by 114% compared to no Zn application. Additionally, Zn application decreased grain As concentration at all As levels. In conclusion, this study suggests that applying Zn to Zn‐biofortified wheat irrigated with As‐contaminated water can mitigate the toxic effects of As on wheat. It increase Zn concentration and decrease As concentration in wheat grains, which is vital for enhancing grain quality for human consumption.

SODIUM NITRITE (E250) AND ZINC AS MODULATORS OF THE BIOMECHANICAL PROPERTIES OF BLOOD IN SPORTS

Nutritional supplements are often used by athletes to support their performance. However, if there is no nutrient deficiency, supplementation may not improve performance and may even have a detrimental effect on both performance and health. The aim of this study was to review the influence of sodium nitrite (NaNO2) and zinc (Zn) on the hemorheological status of different types of blood cells with application in sports. Sodium nitrite, known as food preservative E250, and zinc are proven modulators of the biomechanical properties of blood, influencing its hematometric and hemorheological properties. Our previous experimental results demonstrated that intraperitoneal injection of NaNO2 in mature rats had a diverse effect on the leukocyte and platelet populations. After the treatment, the number of monocytes and granulocytes decreased significantly, thus increasing the susceptibility to infections. The number of platelets increased, altering the coagulation status of blood. Scientific research data show that the proper intake of NaNO2 and Zn improves glucose metabolism, a key factor in maintaining energy levels during physical activity, muscle strength, and endurance. Zn also exhibits protective effects against bone loss. Excessive intake of zinc for long periods may interfere with other essential elements of metabolism. This review proves that hemorheological parameters such as whole blood viscosity, plasma viscosity, as well as the main hematometric indices are suitable quantitative biological markers for monitoring nitrite and/or zinc supplementation.

Is There a Relationship Between the Dietary Inflammatory Index and Clinical Attachment Loss in Patients with Periodontitis?

Objective The pathogenesis of periodontal diseases is partially driven by oxidative stress. However, studies on the relationship between periodontitis and the inflammatory load of diet are still insufficient. Therefore, this study aimed to examine the relationship between the diet’s inflammatory load and periodontitis and clinical attachment loss (CAL). Methods This cross-sectional study included 119 participants diagnosed with periodontitis according to the 1999 classification. The dietary inflammatory index (DII) was calculated using three-day food consumption records and divided into quartiles (Q1, Q2, and Q3). Body mass index (BMI) was calculated as weight and height (kg/m2). Clinical attachment loss (CAL) score was determined, and the patients were grouped with those CAL scores as 7 < CAL and ≥7 CAL. Results Of the 119 patients with periodontitis, aged 46.24 ± 12.84 years, 45.3% were found to have an anti-inflammatory diet profile (n = 54). When the daily energy and nutrient intake of individuals were examined, it was found that the intake of omega-3 fatty acids (p = 0.004), black tea (p = 0.021), and green pepper (p = 0.029) was higher in those with CAL < 7 compared to those with CAL ≥ 7. There was no relationship between the patients’ DII and CAL values. Daily energy, protein, fiber, vitamin A, vitamin E, folic acid, Fe, Zn, and Mg intake in patients with an anti-inflammatory diet in Q1 were higher than in Q2 and Q3 (p < 0.001). Conclusion This study found no relationship between DII levels and CAL scores. However, it was observed that periodontitis patients following an anti-inflammatory diet had higher intakes of omega-3 fatty acids, vitamins A, E, and C, as well as zinc and magnesium which are nutrients known to be effective against inflammation. These patients also had CAL scores below 7. Therefore, reducing the inflammatory load of the diet may prevent the development of periodontitis, and further research in this regard would be beneficial.

Two Doses of Zn Induced Different Microbiota Profiles and Dietary Zinc Supplementation Affects the Intestinal Microbial Profile, Intestinal Microarchitecture and Immune Response in Pigeons.

We aimed to explore the effects of two different doses of Zn on the fecal microbiota in pigeons and the correlation between these effects and intestinal immune status. Zn doses affected pigeon growth performance, and pigeons in the T60 (60 mg/kg Zn) and T90 (90 mg/kg Zn) groups exhibited higher villus height and crypt depth in duodenum and ileum compared to the control group, respectively. Supplementation with Zn increased the expression of the IL8, CD798, TJP and NKTR genes (p < 0.05), while enhancing serum immunoglobulin (Ig) G, IgM, and IgA concentrations compared to the control pigeons (p < 0.05). T60 treatment reduced relative Actinobacteriota abundance, while Lactobacillus spp. abundance was highest in the T90 group compared to the two other groups. The core functional genera significantly associated with immune indices in these pigeons were Rhodococcus erythropolis and Lactobacillus ponti. Our findings will help facilitate the application of dietary Zn intake in pig production.

Modeling the Contribution of Multiple Micronutrient Fortification of Salt to Daily Nutrient Intake Among the Ethiopian Population

BackgroundSalt is an affordable commodity and has wide coverage regardless of economic and social status and, hence, could be suitable vehicle for multiple micronutrient fortification. ObjectivesThis study aimed to simulate the contribution folic acid and zinc fortification of iodized salt to nutrient intake among the Ethiopian population. MethodsThe 2013 Ethiopian National Food Consumption Survey and various food composition tables were used to estimate baseline individual-level micronutrient intake. Usual intake was estimated using the Simulating Intake of Micronutrients for Policy Learning and Engagement macro tool. Discretionary salt consumption was calculated from total salt intake estimated using urinary sodium excretion. Fortificant addition rates were set to obtain maximum nutrient intake while simultaneously constraining that population with intake above the tolerable upper intake level to <5%. Addis Ababa and Somali (N = 2271), the regions with relatively the lowest and highest micronutrient deficiency prevalence in Ethiopia, were selected. ResultBaseline median intake of Zn was below the estimated average requirement for all demographic groups. Inadequate Zn intake ranged from 73% to 99%, the highest prevalence being observed among women in lower class of wealth quintiles from Somali region. Dietary folate inadequacy was as low as 2% among men in Addis Ababa but almost all (99%) women from Somali region had inadequate folate intake. Calculated discretionary salt intake was 7.5 g/d for adult men and women and 3.4 g/d for children. With addition 0.8 mg Zn and 30 μg of folic acid per gram of salt, multiple salt fortification is estimated to reduce Zn inadequacy by 38 percentage points in urban areas and19 percentage points in rural areas. Modeled reduction in folate inadequacy were 18% in urban areas and 22% in rural areas. ConclusionsMultiple salt fortification could be an effective approach to address micronutrient adequacy in Ethiopia given efficacious, technological, and economical feasibility.

Modulation of Adverse Health Effects of Environmental Cadmium Exposure by Zinc and Its Transporters.

Zinc (Zn) is the second most abundant metal in the human body and is essential for the function of 10% of all proteins. As metals cannot be synthesized or degraded, they must be assimilated from the diet by specialized transport proteins, which unfortunately also provide an entry route for the toxic metal pollutant cadmium (Cd). The intestinal absorption of Zn depends on the composition of food that is consumed, firstly the amount of Zn itself and then the quantity of other food constituents such as phytate, protein, and calcium (Ca). In cells, Zn is involved in the regulation of intermediary metabolism, gene expression, cell growth, differentiation, apoptosis, and antioxidant defense mechanisms. The cellular influx, efflux, subcellular compartmentalization, and trafficking of Zn are coordinated by transporter proteins, solute-linked carriers 30A and 39A (SLC30A and SLC39A), known as the ZnT and Zrt/Irt-like protein (ZIP). Because of its chemical similarity with Zn and Ca, Cd disrupts the physiological functions of both. The concurrent induction of a Zn efflux transporter ZnT1 (SLC30A1) and metallothionein by Cd disrupts the homeostasis and reduces the bioavailability of Zn. The present review highlights the increased mortality and the severity of various diseases among Cd-exposed persons and the roles of Zn and other transport proteins in the manifestation of Cd cytotoxicity. Special emphasis is given to Zn intake levels that may lower the risk of vision loss and bone fracture associated with Cd exposure. The difficult challenge of determining a permissible intake level of Cd is discussed in relation to the recommended dietary Zn intake levels.

Zinc transporters expression profile in professional handball players supplemented with zinc

IntroductionZinc (Zn) deficiency has been described not only on general human health but also within the sports context –as negatively affecting performance–. Thus, Zn status assessment is of great interest for athletes, especially in order to correct deficiency states of this mineral. ObjectiveThe overall objective of this work was to assess Zn status in professional handball players during the competitive period (through plasma levels, dietary intake and gene expression of the Zn transporters), as well as to determine the effect of Zn supplementation. MethodsA total of twenty-two participants were recruited, –twelve belonged to the Control Group (CG) and ten male handball players comprised the experimental group (ATH-G)–, being monitored over a 2-month period with 2 evaluation moments: baseline (i.e., initial conditions) and follow-up (i.e., after 8 weeks of training and competition). Zn intake, plasma Zn levels, and gene expression of Zn transporters were obtained. ResultsPlasma Zn levels were higher in ATH-G than in CG at the end of Zn intervention (p ≤ 0.010). Moreover, differences in the gene expression profile of Zn transporters were observed in ATH-G –with the down-regulation of several Zn transporters–, compared to the CG at baseline (p ≤ 0.05). Likewise, differences in the Zn transporters expression were observed in ATH-G at 8 weeks (all, p ≤ 0.001) –with ZnT2, ZnT5, ZIP3, ZIP5, ZIP11, ZIP13 and ZIP14 transporters being up-regulated–. ConclusionHandball players seemed to have different nutritional needs for Zn, with differences in the gene expression of Zn transporters compared to controls. Zn intervention in our athletes may have influenced the expression of Zn transporters, indicating a potential increase in Zn transporters expression to mobilize Zn at the cellular level at 8 weeks of Zn intervention.

Zinc, antioxidant enzymes in preeclampsia, and association with newborn outcome

BackgroundThe etiology of preeclampsia (PE) may be associated with the increased of production of reactive species and decreased antioxidant activity of enzymes. Inadequate intake of Zn can affect gestational health due to its biological functions, such as its role in the antioxidant defense system. The study aimed to assess the nutritional status of Zn and antioxidant enzymes in postpartum women and its correlation with neonatal outcomes. MethodsA cross-sectional analytical study was carried out at a referral gynecology and obstetrics hospital. A total of 119 women (PE = 58, HP = 61) participated in the study. A quantitative food-frequency questionnaire was used to assess food consumption and further analyze the dietary Zn levels.Zinc levels in plasma and erythrocytes samples were analyzed by flame atomic absorption spectrometry, catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) levels were determined by UV-Vis spectrophotometry. ResultsPlasma and dietary intake Zn results were considered adequate and without statistical difference between groups. SOD levels were significantly higher in the HP group (p = 0.011), and CAT levels were higher in the PE group (p = 0.050). There was a positive correlation between SOD activity in women with PE and the weight of their newborns (r = 0.336, p=0.021). ConclusionThe results showed adequate Zn levels (consumption and serum levels) in the groups studied, although with a reduction of plasma Zn in the PE group compared to the PH group.Zinc in plasma fractions and erythrocytes are important markers for oxidative stress, in particular, plasma Zn seems to be related to the rapid response to preeclampsia. The activity of antioxidant enzymes was elevated in the groups studied. Better SOD activity improves birth weight in children of pregnant women with preeclampsia.

Assessment of macro, trace and toxic element intake from rice: differences between cultivars, pigmented and non-pigmented rice

Pigmented and non-pigmented rice varieties (grown in different areas) were collected in China, Yunnan, to investigate the content of macro-, trace elements and potentially toxic elements (PTEs), and to assess the health risk associated with dietary intake. The order of elemental concentrations in rice was Mn > Zn > Fe > Cu > Se for trace elements, P > K > Mg > Ca > Na for macro elements, and Cr > As > Cd for PTEs. Rice with a high concentration of essential elements also associated with a high content of PTEs. In addition, higher content of Cr, Mn and Na were found in pigmented rice. The health risk assessment showed that the daily intake of all elements was below the tolerable limit (UL). Moreover the intake of Fe, Zn and Se was far from sufficient for the nutrient requirement. The PTEs in rice dominated the health risk. Of concern is that this rice consumption is likely to contribute to carcinogenic risks in the long term and that adults are at higher health risk from pigmented rice compared to non-pigmented rice. This study confirms that the lack of essential micronutrients in rice and the health risk associated with rice diets should remain a concern.

Detection of Heavy Metals in Some Edible Grains Obtained from Two Markets in Bauchi Metropolis, Nigeria

This study investigated the level of heavy metals (Cd, Cr, Cu, Fe, Pb and Zn) in grains sold in Central and Muda Lawal markets in Bauchi. Our objectives include assessing heavy metal concentrations in the grains and evaluating associated health risks. We utilized Atomic Absorption Spectrophotometry following acid digestion of grains to determine heavy metal concentrations. In Central market-sourced crops, the mean concentrations of Cd, Cr, Cu, Fe, Pb, and Zn were 0.06, 0.49, 0.21, 1.16, 0.15, and 0.17mg/kg respectively. Meanwhile, crops from Muda Lawal market exhibited mean concentrations of 0.06, 0.58, 0.17, 1.62, 0.1, and 0.22 mg/kg for Cd, Cr, Cu, Fe, Pb, and Zn, respectively. Cd, Cr, Cu, Pb, and Zn levels were below the permissible limits. However, Fe exceeded permissible limits in small beans, Syria maize, and white guinea corn from Central market, as well as in Syria maize, Pearl millet II, and white guinea corn from Muda Lawal market. The daily intake of Cd, Cu, and Pb from most studied crops exceeded the oral reference dose, posing potential health risks. Conversely, Cr, Fe, and Zn intake levels were within acceptable limits, posing minimal health risks. Hazard quotient and hazard index values were below 1, suggesting that crop consumption is unlikely to pose health risks.

Identification and prediction of association patterns between nutrient intake and anemia using machine learning techniques: results from a cross-sectional study with university female students from Palestine

PurposeThis study utilized data mining and machine learning (ML) techniques to identify new patterns and classifications of the associations between nutrient intake and anemia among university students.MethodsWe employed K-means clustering analysis algorithm and Decision Tree (DT) technique to identify the association between anemia and vitamin and mineral intakes. We normalized and balanced the data based on anemia weighted clusters for improving ML models’ accuracy. In addition, t-tests and Analysis of Variance (ANOVA) were performed to identify significant differences between the clusters. We evaluated the models on a balanced dataset of 755 female participants from the Hebron district in Palestine.ResultsOur study found that 34.8% of the participants were anemic. The intake of various micronutrients (i.e., folate, Vit A, B5, B6, B12, C, E, Ca, Fe, and Mg) was below RDA/AI values, which indicated an overall unbalanced malnutrition in the present cohort. Anemia was significantly associated with intakes of energy, protein, fat, Vit B1, B5, B6, C, Mg, Cu and Zn. On the other hand, intakes of protein, Vit B2, B5, B6, C, E, choline, folate, phosphorus, Mn and Zn were significantly lower in anemic than in non-anemic subjects. DT classification models for vitamins and minerals (accuracy rate: 82.1%) identified an inverse association between intakes of Vit B2, B3, B5, B6, B12, E, folate, Zn, Mg, Fe and Mn and prevalence of anemia.ConclusionsBesides the nutrients commonly known to be linked to anemia—like folate, Vit B6, C, B12, or Fe—the cluster analyses in the present cohort of young female university students have also found choline, Vit E, B2, Zn, Mg, Mn, and phosphorus as additional nutrients that might relate to the development of anemia. Further research is needed to elucidate if the intake of these nutrients might influence the risk of anemia.

Immunomodulatory Effects of Vitamin D and Zinc on Viral Infection.

Several nutrients are crucial in enhancing the immune system and preserving the structural integrity of bodily tissue barriers. Vitamin D (VD) and zinc (Zn) have received considerable interest due to their immunomodulatory properties and ability to enhance the body's immune defenses. Due to their antiviral, anti-inflammatory, antioxidative, and immunomodulatory properties, the two nutritional powerhouses VD and Zn are crucial for innate and adaptive immunity. As observed with COVID-19, deficiencies in these micronutrients impair immune responses, increasing susceptibility to viral infections and severe disease. Ensuring an adequate intake of VD and Zn emerges as a promising strategy for fortifying the immune system. Ongoing clinical trials are actively investigating their potential therapeutic advantages. Beyond the immediate context of the pandemic, these micronutrients offer valuable tools for enhancing immunity and overall well-being, especially in the face of future viral threats. This analysis emphasizes the enduring significance of VD and Zn as both treatment and preventive measures against potential viral challenges beyond the current health crisis. The overview delves into the immunomodulatory potential of VD and Zn in combating viral infections, with particular attention to their effects on animals. It provides a comprehensive summary of current research findings regarding their individual and synergistic impacts on immune function, underlining their potential in treating and preventing viral infections. Overall, this overview underscores the need for further research to understand how VD and Zn can modulate the immune response in combatting viral diseases in animals.

Analysis of macronutrient and micronutrient intake with the incidence of stunting and wasting in toddlers 0-59 months of age at public health center Bojong, Bogor regency

Background : Stunting is defined as not achieving optimal height for age. One of the factors of stunting is caused by unbalanced nutrition. This is due to long-term nutrient intake inadequacies that potentially lead to insufficient nutrient requirements from food. Wasting often has symptoms of severe weight loss in the short term. It usually occurs when toddlers do not get a good quality and quantity of food and/or they suffer from recurrent or chronic illnesses.&#x0D; Objective : Assessing the relationship between macro-micronutrient intake with the incidence of stunting and wasting in the Bojong Health Center working area, Bogor Regency July-August 2023 Period.&#x0D; Methods : This research using cross-sectional study was conducted in the working area of Public Health Centre Bojong, Bogor Regency, Indonesia, from July 2023 to August 2023. The number of subjects is 93 subjects. Subjects were recruited using consecutive sampling, toddlers aged 0-59 months and mothers were the respondents who answered questions during interviews, 2x24-hour food recall, SQFFQ. The data in this study was obtained through direct interviews with respondents.&#x0D; Results : Subject macronutrient and micronutrient intake tended to be deficient refer to RDA 2019. There was an association (p=0.000) between the intake of energy, protein, carbohydrates, fat, Fe, Omega 3, Zn, vitamin D, and Ca with the incidence of stunting and wasting.&#x0D; Conclusions : Intakes of energy, protein, carbohydrate, fat, iron, omega-3, zinc, vitamin D, and Ca were significantly lower in children with nutritional problems (stunting and wasting) compared to RDA Indonesian Ministry of Health 2019.

Association of Zinc Intake, Tobacco Smoke Exposure, With Metabolic Syndrome: Evidence from NHANES 2007-2018.

The objective was to explore the effect modification of zinc (Zn) intake levels on the relationship of tobacco smoke exposure and risk of metabolic syndrome (MetS) in children and adolescents. We used data from 2007-2018 National Health and Nutrition Examination Survey (N = 3701). MetS was considered as main endpoint. Weighted multivariable logistic regression models showed that high cotinine level (≥ 0.05ng/mL) was associated with increased odds of MetS [odds ratio = 1.54, 95% confidence interval: 1.01, 2.36], and the association between Zn intake levels and MetS did not demonstrate statistical significance. Importantly, the multiplicative interaction term between low Zn intake (≤ 4.89mg/1000kcal) and high cotinine level was related to higher odds of MetS (p-value for interaction 0.018). For the group with low Zn intake, high cotinine level was associated with increased odds of MetS. However, there was no significant relationship between cotinine levels and MetS risk in the group with high Zn intake. The effect modification by Zn intake on the relationship of tobacco smoke exposure and risk of MetS is significant in individuals who had a sedentary time of ≥ 6h, identified as non-Hispanic White, or resided in households with smokers. In short, low Zn intake may potentiate the association of tobacco smoke exposure and MetS risk in children and adolescents.

Potentially toxic elements in soil-plant-water-animal continuum in a mining area from Northwestern Mexico: animal exposure pathways and health risks for children.

Mining increases environmental concentrations of potentially toxic elements (PTEs) accumulating in organisms and spreading in the human food chain-their presence in milk is of great human health concern. Pathways were identified by which these elements reach raw milk from farms within a mining area in Northwestern Mexico; health risks for dairy cattle and children were also evaluated. Water from river and cattle waterers, as well as, soils showed that PTE concentrations generally below the Mexican and international limits; cattle forage concentrations were above the World Health Organization limits. Al, Mg, Mo, Ni and Zn were recorded in raw milk samples from the mining area, showing that Cd, Co, Cr, Cu, Pb and V are transferred from soil to plants but not accumulated in raw milk. Zn concentrations in raw milk exceeded the permissible limit; milk from farms without mining operations (comparison site) showed the presence of Al, Cr and Cu. In cattle tail hair, PTE did not correlate with raw milk concentrations. Metal accumulation in milk was higher through water consumption than that accumulated through forage consumption. Daily intakes (DI) of Al, Mg and Zn in cows could represent a risk for their health. The observed biotransference was higher than in other parts of Mexico, and the calculated DI and hazard quotients indicate no adverse health effects for children. However, the hazard Index values indicate that exposure to multiple PTE represents a risk for children. Management measures should be performed to control the cumulative risks to protect young children's health.

The Nutritional Value of Plant Drink against Bovine Milk—Analysis of the Total Concentrations and the Bio-Accessible Fraction of Elements in Cow Milk and Plant-Based Beverages

Four types of non-dairy (plant) drinks—almond, oat, rice, and soy—as well as cow milk with varying fat contents (1.5%, 2.0%, and 3.2%), were examined and compared in terms of the total concentrations of Al, As, B, Ba, Ca, Cd, Cr, Cu, Fe, K, Mg, Na, Mn, Ni, P, Pb, Sb, Se, Sr, and Zn using inductively coupled optical emission spectrometry (ICP OES). Additionally, in vitro gastrointestinal digestion was used to determine the bio-accessible fraction of selected elements, evaluating the nutritional value and risk assessment involved with the consumption of these beverages. A significant difference in the mineral profile was observed depending on the type of plant drink, with the highest content of elements noted in the soy drink and the lowest in the rice drink. Except for Ca and P, the soy drink appears to be a much better source of essential nutrients, including Cu, Fe, and Mn, than cow’s milk. A similar Ca content in plant beverages can be obtained only by adding calcium salt at the stage of its production. Interestingly, by using the multivariate data analysis, the average content of the selected elements (Cu, K, Na, P, and Zn) can be used both to differentiate dairy and non-dairy milk samples according to their type and to distinguish plant drinks from milk of animal origin. The bio-accessibility of essential elements (Ca, Cu, Fe, Mg, Mn, P, Zn) in cow milk was within 8.37–98.2% and increased with an increase in its fat content. Accordingly, by drinking 1 L of this milk daily, it is possible to contribute to the recommended dietary intakes of Ca, P, Cu, Mg, and Zn between 5.6–68%. Although the bio-accessibility of elements in the rice drink was the highest (9.0–90.8%), the soy drink seems to be the best source of nutrients in bioavailable forms; its consumption (1 L/day) covers the requirements of Cu, Mn, Mg, Ca, P, and Zn in 7.0–67%. Unfortunately, both groups of beverages are not important sources of Fe (plant drink) and Mn or Fe (cow milk) in the human diet. On the other hand, potentially toxic elements (Al, B, Ba) were found in them in a relatively inert form.