Event Abstract Back to Event EEG alpha power and methadone treatment Grace Y. Wang1, 2*, Trecia A. Wouldes3, Rob Kydd3 and Bruce R. Russell1, 2 1 The University of Auckland, School of Pharmacy, New Zealand 2 The University of Auckland, Centre of Brain Research, New Zealand 3 The University of Auckland, Department of Psychological Medicine, New Zealand Background: A small number of studies conducted mostly during the 70’s have examined EEG changes in patients undertaking methadone maintenance treatment (MMT) during resting states and have shown inconsistent effects of MMT on brain function. Some of the inconsistencies may have arisen because of differences in sample size and variations in the inclusion criteria of participants. Objective: The objective of this study was to address the limitations of earlier research by examining the effect of MMT on resting alpha rhythm using electroencephalography (EEG). Method: The average power of alpha (8-13 Hz) rhythm was measured in 32 MMT patients, 17 opiate users and 25 healthy volunteers. A one-way analysis of variance with group as a fixed factor with age and years of education entered as covariates tested the differences between groups. Post-hoc comparisons were Bonferroni corrected. Results: During the eyes open condition, a significantly higher alpha amplitude was found in active opiate users in contrast to healthy controls in the frontal (F=4.93, p=0.01), central (F=4.25, p=0.02), temporal (F=5.28, p=0.007) and parietal-occipital regions (F=3.85, p=0.03). There was no difference either between the MMT group and healthy controls or between the MMT and opiate groups. Furthermore, there were no group differences in alpha power during the eyes closed condition. Conclusion: The abnormal electrical neural activity presented in active opiate users may be minimised following chronic MMT. The normalising effect of MMT may be related to a low level of sustained activation of the opiate receptors with proper dosing of methadone. Acknowledgements Funding for this study was provided by New Zealand Pharmacy Education Research Funding (NZPERF) References Feinstein, B., & Hanley, J. (1975). EEG findings in heroin addicts during induction and maintenance on methadone [Research Support, U.S. Gov't, Non-P.H.S.]. Electroencephalography & Clinical Neurophysiology, 39(1), 96-99. Fingelkurts, A. A., Fingelkurts, A. A., Kivisaari, R., Autti, T., Borisov, S., Puuskari, V., Kähkönen, S. (2007). Composition of EEG Oscillations and their Temporal Characteristics International Journal of Psychophysiology. Fingelkurts, A. A., Fingelkurts, A. A., Kivisaari, R., Autti, T., Borisov, S., Puuskari, V., Kähkönen, S. (2009). Methadone restores local and remote EEG functional connectivity in opioid. International Journal of Neuroscience 119(9), 1469-1493. Lenn, N. J., Senay, E. C., Renault, P. F., & Deuel, R. K. (1976). Neurological assessment of patients on prolonged methadone maintenance [Research Support, U.S. Gov't, Non-P.H.S.]. Drug & Alcohol Dependence, 1(4), 305-311. Martin, W. R., Jasinski, D. R., Haertzen, C. A., Kay, D. C., Jones, B. E., Mansky, P. A., & Carpenter, R. W. (1973). Methadone--a reevaluation. Archives of General Psychiatry, 28(2), 286-295. Keywords: Methadone treatment, Opiates, Alpha power, resting EEG, opiate receptors Conference: ACNS-2012 Australasian Cognitive Neuroscience Conference, Brisbane, Australia, 29 Nov - 2 Dec, 2012. Presentation Type: Poster Presentation Topic: Other Citation: Wang GY, Wouldes TA, Kydd R and Russell BR (2012). EEG alpha power and methadone treatment. Conference Abstract: ACNS-2012 Australasian Cognitive Neuroscience Conference. doi: 10.3389/conf.fnhum.2012.208.00111 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 25 Oct 2012; Published Online: 07 Nov 2012. * Correspondence: Ms. Grace Y Wang, The University of Auckland, School of Pharmacy, Auckland, New Zealand, g.wang@auckland.ac.nz Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Grace Y Wang Trecia A Wouldes Rob Kydd Bruce R Russell Google Grace Y Wang Trecia A Wouldes Rob Kydd Bruce R Russell Google Scholar Grace Y Wang Trecia A Wouldes Rob Kydd Bruce R Russell PubMed Grace Y Wang Trecia A Wouldes Rob Kydd Bruce R Russell Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.