The outbreak of sexually transmitted infections (STIs) in the nation is not something new; in fact, the issue has been around for many years and has been steadily becoming worse over that time. The problem becomes more crucial as each year; an increasing number of cases will be reported in Malaysia and throughout the world. In some cases, symptoms of STIs may not even be present. This can mean that a person might get infected by another person who might appear healthy without knowing they have already been infected with STIs; therefore, this article aims to investigate the knowledge, attitudes, and environment as the factors that influence awareness of Sexual Transmitted Infections (STIS) among the 227 of youths. A survey was conducted, and the data was analyzed using regression analysis. The result revealed that knowledge, attitude, and environment had a significant influence on sexually transmitted infections. In addition, the environmental factor reported had the most significant influence. The finding implies that external roles, such as those of the government, schools, and universities, should be provided with more facilities and programs to sustain and improve awareness among the youth group. Furthermore, increasing youth awareness may change individual behavior and attitude toward a good, healthy lifestyle.